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The remarkably higher reactivity of GPx enzyme as compared to the fully dissociated synthetic selenolate\/thiolate molecule is probably due to the dual\u2010attack on the peroxide bond (HO\n                    <jats:sup>1<\/jats:sup>\n                    \u2212O\n                    <jats:sup>2<\/jats:sup>\n                    H) by the enzyme; The first one is a nucleophilic attack of the selenolate\/thiolate moiety to O\n                    <jats:sup>1<\/jats:sup>\n                    atom and the second attack at the O\n                    <jats:sup>2<\/jats:sup>\n                    atom of the peroxide bond by the acidic \u201cparked proton\u201d from Trp or His residue present at the enzyme's active site, leading to the facile cleavage of O\u2212O bond. Herein, we report two synthetic compounds (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ), having a selenolate (Se\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and a proton donor (imidazolium or \u2212COOH group) moieties, which showed excellent GPx\u2010like activity via dual\u2010attack on the peroxide bond. The combined effect of selenolate moiety that donates electrons to the antibonding (\u03c3*) orbital of O\n                    <jats:sup>1<\/jats:sup>\n                    \u2212O\n                    <jats:sup>2<\/jats:sup>\n                    bond and the imidazolium or carboxylic acid moiety at the side chain that forms a strong H\u2010bonding with the O\n                    <jats:sup>2<\/jats:sup>\n                    atom facilitates O\u2212O bond cleavage of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    more efficiently.\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    exhibit remarkable ability in protecting Cu(I)\u2010complex [TpmCu(CH\n                    <jats:sub>3<\/jats:sub>\n                    CN)]\n                    <jats:sup>+<\/jats:sup>\n                    (\n                    <jats:bold>9<\/jats:bold>\n                    ) against H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    by acting as a sacrificial antioxidant, thereby preventing metal\u2010mediated ROS production.\n                  <\/jats:p>","DOI":"10.1002\/chem.202403483","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T08:40:34Z","timestamp":1729154434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cleavage of a Peroxide Bond\n                    <i>via<\/i>\n                    a Dual Attack by Functional Mimics of Glutathione Peroxidase"],"prefix":"10.1002","volume":"31","author":[{"given":"Rakesh","family":"Kumar Rai","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Tirupati  Tirupati, A.P. 517619 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