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However, the role of CO<jats:sub>2<\/jats:sub> in prebiotic chemistry has been predominantly and limitedly postulated as a C1 precursor, which can be reduced to carbon monoxide or methane mimicking the Wood\u2010Ljungdahl pathway. Herein we present neglected roles of CO<jats:sub>2<\/jats:sub> as an active promoter in accessing biologically important C3\u2010builidng blocks such as lactate, via redox\u2010economic reaction cycles starting from cyanide (C1) and acetaldehyde (C2). We verified that Lewis acidic CO<jats:sub>2<\/jats:sub> facilitates the formation of cyanohydrin of acetaldehyde under ambient conditions. Furthermore, selective protection of cyanohydrin to carbonate by atmospheric CO<jats:sub>2<\/jats:sub> led to anchimeric assisted hydrolysis of the nitrile group to generate lactate. This work supports both warm pond and hydrothermal vent hypotheses, postulating that a CO<jats:sub>2<\/jats:sub>\u2010rich primordial atmosphere and the acidic aqueous solution could have fostered the emergence of biologically relevant molecules and life itself.<\/jats:p>","DOI":"10.1002\/chem.202403763","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T13:53:39Z","timestamp":1735307619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Prebiotic Route to Lactate from Acetaldehyde, Cyanide and Carbon Dioxide"],"prefix":"10.1002","volume":"31","author":[{"given":"Shriaya","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Chemistry Nano-Science Center University of Copenhagen  Universitetsparken 5 Copenhagen \u00d8 2100 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Nano-Science Center University of Copenhagen  Universitetsparken 5 Copenhagen \u00d8 2100 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6177-4569","authenticated-orcid":false,"given":"Ji\u2010Woong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry Nano-Science Center University of Copenhagen  Universitetsparken 5 Copenhagen \u00d8 2100 Denmark"},{"name":"The Novo Nordisk Foundation CO<sub>2<\/sub> Research Center  Gustav Wieds Vej 10\u2005C 8000 Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8524(01)00118-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2017.00007"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2365"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.1.200"},{"key":"e_1_2_7_6_1","unstructured":"\u00a0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00151"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1913"},{"key":"e_1_2_7_9_1","unstructured":"\u00a0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.52.4.452-484.1988"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-021-00789-w"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36088-w"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1991"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33741-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1881"},{"key":"e_1_2_7_16_1","unstructured":"\u00a0"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5483.1337"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5310.245"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay4644"},{"key":"e_1_2_7_20_1","unstructured":"\u00a0"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm2296"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721296115"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","unstructured":"M. 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