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The dehydrogenation reaction can be conducted with a green terminal oxidant O<jats:sub>2<\/jats:sub> without requiring strong acid\/base or stoichiometric oxidants. The Cu(II) complex\/TEMPO\/O<jats:sub>2<\/jats:sub> system uses a non\u2010noble catalyst, and a green terminal oxidant as well as demonstrates high activity and functional group tolerance. Notably, H<jats:sub>2<\/jats:sub>O is the byproduct produced and overoxidation is not observed during the reaction process. The proposed mechanism was investigated via high\u2010resolution mass spectrometry (HRMS), <jats:italic>in\u2005situ<\/jats:italic> FT\u2010IR spectrometry, and GC analysis, and the formation of intermediates of <jats:italic>\u03b1<\/jats:italic>,<jats:italic>\u03b2<\/jats:italic>\u2010unsaturated carbonyl compounds from the aerobic dehydrogenation of <jats:italic>\u03b1<\/jats:italic>,<jats:italic>\u03b2<\/jats:italic>\u2010saturated counterparts was observed.<\/jats:p>","DOI":"10.1002\/chem.202403950","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T23:50:28Z","timestamp":1736380228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis of <i>\u03b1,\u03b2\u2010<\/i>Unsaturated Carbonyl Compounds via Cu\/TEMPO\/O<sub>2<\/sub> Aerobic Catalytic System"],"prefix":"10.1002","volume":"31","author":[{"given":"Yao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi University  Xinjiang 832003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7408-3588","authenticated-orcid":false,"given":"Zhi\u2010Hong","family":"Du","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi University  Xinjiang 832003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbo","family":"Bo","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi University  Xinjiang 832003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi University  Xinjiang 832003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4318-6081","authenticated-orcid":false,"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi University  Xinjiang 832003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-0400","authenticated-orcid":false,"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering\/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi University  Xinjiang 832003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr900202j"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr1003503"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00833"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00064a028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00218a062"},{"key":"e_1_2_8_7_1","unstructured":"\u00a0"},{"key":"e_1_2_8_8_2","first-page":"7591","volume":"122","author":"Nicolaou K. 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