{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:58:57Z","timestamp":1791899937568,"version":"4.3.4"},"reference-count":82,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003151","name":"Fonds de recherche du Qu\u00e9bec \u2013 Nature et technologies","doi-asserted-by":"publisher","award":["2020-RS4-265155-CCVC"],"award-info":[{"award-number":["2020-RS4-265155-CCVC"]}],"id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2025,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The pentafluorosulfanyl (SF\n                    <jats:sub>5<\/jats:sub>\n                    \u2212) group has been the subject of a surge of interest in the past decade, but there is still little practicality associated with its synthesis and installation. Herein is reported the first continuous flow synthesis of pentafluorosulfanyl chloride (SF\n                    <jats:sub>5<\/jats:sub>\n                    Cl), the most common reagent for the synthesis of SF\n                    <jats:sub>5<\/jats:sub>\n                    \u2010substituted compounds. The synthesis is based on inexpensive and easy\u2010to\u2010handle reagents: sulfur powder (S\n                    <jats:sub>8<\/jats:sub>\n                    ), trichloroisocyanuric acid (TCCA) and potassium fluoride (KF). To this end, a custom\u2010made stirring reactor was designed to allow for fast, safe, and highly efficient on\u2010demand synthesis of SF\n                    <jats:sub>5<\/jats:sub>\n                    Cl. The resulting SF\n                    <jats:sub>5<\/jats:sub>\n                    Cl solution is showcased in the radical addition on alkynes in a telescoped fashion.\n                  <\/jats:p>","DOI":"10.1002\/chem.202404039","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T23:16:11Z","timestamp":1736982971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["On\u2010Demand Continuous Flow Synthesis of Pentafluorosulfanyl Chloride (SF\n                    <sub>5<\/sub>\n                    Cl) Using a Custom\u2010Made Stirring Packed\u2010Bed Reactor"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4359-8877","authenticated-orcid":false,"given":"Lauriane C.","family":"Peyrical","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, FRQNT Centre in Green Chemistry and Catalysis, Centre for Continuous Flow Synthesis, Department of Chemistry, 1375 av. Th\u00e9r\u00e8se Lavoie-Roux  Montr\u00e9al, QC, H2V 0B3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-427X","authenticated-orcid":false,"given":"Thibaud","family":"Mabit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, FRQNT Centre in Green Chemistry and Catalysis, Centre for Continuous Flow Synthesis, Department of Chemistry, 1375 av. Th\u00e9r\u00e8se Lavoie-Roux  Montr\u00e9al, QC, H2V 0B3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-7203","authenticated-orcid":false,"given":"Vanessa","family":"Kairouz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, FRQNT Centre in Green Chemistry and Catalysis, Centre for Continuous Flow Synthesis, Department of Chemistry, 1375 av. Th\u00e9r\u00e8se Lavoie-Roux  Montr\u00e9al, QC, H2V 0B3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-5063","authenticated-orcid":false,"given":"Andr\u00e9 B.","family":"Charette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, FRQNT Centre in Green Chemistry and Catalysis, Centre for Continuous Flow Synthesis, Department of Chemistry, 1375 av. Th\u00e9r\u00e8se Lavoie-Roux  Montr\u00e9al, QC, H2V 0B3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"For recent reviews see:"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr500336u"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202201491"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202200904"},{"key":"e_1_2_8_5_2","author":"Abd El Sater M.","year":"2024","journal-title":"Synthesis"},{"key":"e_1_2_8_6_1","unstructured":"\u00a0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC04846E"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade5320"},{"key":"e_1_2_8_9_1","unstructured":"\u00a0"},{"key":"e_1_2_8_10_2","first-page":"12822","volume":"7","author":"Chan J. M. W.","year":"2019","journal-title":"J. Mater. 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Chem. Int. Ed."},{"key":"e_1_2_8_48_2","doi-asserted-by":"crossref","unstructured":"For a recent review: G. Haufe Tetrahedron2022 109 132656.","DOI":"10.1016\/j.tet.2022.132656"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202103606"},{"key":"e_1_2_8_50_1","doi-asserted-by":"crossref","unstructured":"Review on ex situ strategy: J. Demaerel C. Veryser W.\u2005M. De Borggraeve React. Chem. Eng.2020 5 615\u2013631.","DOI":"10.1039\/C9RE00497A"},{"key":"e_1_2_8_51_1","unstructured":"\u00a0"},{"key":"e_1_2_8_52_2","doi-asserted-by":"crossref","unstructured":"A. Taponard T. Jarrosson L. Khrouz M. M\u00e9debielle J. Broggi A. Tlili Angew. Chem. Int. Ed.2022 61 e202204623;","DOI":"10.1002\/anie.202204623"},{"key":"e_1_2_8_53_2","doi-asserted-by":"crossref","unstructured":"R. Kordnezhadian T. De Bels K. Su L. Van Meervelt E. Ismalaj J. Demaerel W.\u2005M. De Borggraeve Org. 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