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This paper presents a new addition to the list of pyridine ring\u2010opening reactions, reductive Zincke reaction, which affords saturated \u03b4\u2010amino ketones. Under the catalysis of a simple rhodium complex, pyridinium salts with diverse substituents are reduced with formic acid, ring\u2010opened with water, transaminated with a secondary amine and further reduced to afford a wide range of \u03b4\u2010amino ketones, including those in which the alkane chain of the ketones is selectively deuterated or fluorinated. The applicability of the reaction is exemplified by the synthesis of drug analogues and late\u2010stage modification of drug molecules.<\/jats:p>","DOI":"10.1002\/chem.202404043","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T11:34:27Z","timestamp":1734953667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reductive Zincke Reaction: Opening of Pyridinium Rings to \u03b4\u2010Amino Ketones via Transfer Hydrogenation"],"prefix":"10.1002","volume":"31","author":[{"given":"Leiming","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Liverpool  Liverpool L69 7ZD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Liverpool  Liverpool L69 7ZD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"A\u00efssa","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Liverpool  Liverpool L69 7ZD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-247X","authenticated-orcid":false,"given":"Jianliang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Liverpool  Liverpool L69 7ZD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","unstructured":"T.\u2005R. 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