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This study evaluates gadolinium metal\u2010organic frameworks (Gd\u2010MOFs) as potential drug delivery systems for anticancer therapy, particularly when combined with radiotherapy. Gd\u2010MOFs were synthesized using terephthalic acid and gadolinium (III) chloride hexahydrate and then loaded with methotrexate (MTX). Characterization via fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), magnetic resonance imaging (MRI), and X\u2010ray diffraction (XRD) confirmed their correct structure and stability. Effective MTX loading and controlled release were demonstrated. Anticancer effects were assessed on human healthy bronchial epithelial cells (BEAS\u20102B) and human lung cancer cells (A549) using the 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide (MTT) assay under in vitro radiation therapy. MTX\/Gd\u2010MOF combined with radiotherapy showed a greater reduction in cancer cell viability (41.89%\u00a0\u00b1\u00a02.75 for A549) compared to healthy cells (56.80%\u00a0\u00b1\u00a01.97 for BEAS\u20102B), indicating selective cytotoxicity. These findings highlight the potential of Gd\u2010MOFs not only as drug delivery vehicles but also as radiosensitizers, enhancing radiotherapy efficacy and offering promising evidence for their use in combinatory cancer therapies to improve treatment outcomes.<\/jats:p>","DOI":"10.1002\/chem.202404106","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:14:26Z","timestamp":1741860866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dual\u2010Functioning Metal\u2010Organic Frameworks: Methotrexate\u2010Loaded Gadolinium MOFs as Drug Carriers and Radiosensitizers"],"prefix":"10.1002","volume":"31","author":[{"given":"Burcu","family":"Karaca","sequence":"first","affiliation":[{"name":"Institute of Nanotechnology and Biotechnology Istanbul Univeristy\u2010Cerrahpasa  Istanbul 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