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Within bromodomain\u2010containing proteins, various degraders targeting BET family\u2010related targets, for example, BRD4, were developed in the last years. On the other hand, a limited number of PROTACs acting against non\u2010BET proteins were reported so far. Among them, BRD9 was recently linked to oncogenic roles in the tumorigenesis processes, especially in sarcomas and leukemias. Herein, we describe the design and synthesis of a focused collection of new BRD9\u2010targeting degraders based on the [1,2,4]triazolo[4,3\u2010\n                    <jats:italic>a<\/jats:italic>\n                    ]quinoxaline heterocyclic scaffold employing two distinct E3 ubiquitin ligase ligands. Through in silico evaluation, synthesis, binding affinity determination, and in vitro analysis, we identified two new VHL\u2010based PROTACs (\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>9<\/jats:bold>\n                    ), which showed remarkable degradation of the protein of interest and antiproliferative activity in acute myeloid leukemia (AML) cells. Notably, compound\n                    <jats:bold>9<\/jats:bold>\n                    exhibited selective degradation of BRD9 over BRD7. These results enlarge and differentiate the pool of heterobifunctional molecules able to degrade BRD9 through the proteasome machinery, providing a promising reference for the discovery of new tools to further explore both the involvement of this epigenetic regulatory factor in tumor processes and to evaluate novel strategies for AML treatment.\n                  <\/jats:p>","DOI":"10.1002\/chem.202404218","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T10:23:52Z","timestamp":1746699832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unveiling New Triazoloquinoxaline\u2010Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9"],"prefix":"10.1002","volume":"31","author":[{"given":"Martina","family":"Pierri","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Salerno  Via Giovanni Paolo II 132 Fisciano 84084 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Bove","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Vico L. 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