{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:04:49Z","timestamp":1780398289259,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K02148"],"award-info":[{"award-number":["24K02148"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24ama121054"],"award-info":[{"award-number":["JP24ama121054"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dynamic kinetic resolution (DKR) by combining lipase\u2010catalyzed esterification of racemic\n                    <jats:italic>sec\u2010<\/jats:italic>\n                    alcohols and in\u2005situ racemization has been widely studied; however, reports on DKR involving lipase\u2010catalyzed hydrolysis of racemic esters are scarce. This problem is probably due to the lack of more effective and general racemization methods. Herein, we report the enhanced hydrolytic DKR of racemic allylic esters. The discovery of the monodentate ligand P[C\n                    <jats:sub>6<\/jats:sub>\n                    H\n                    <jats:sub>3<\/jats:sub>\n                    \u20102,6\u2010(OMe)\n                    <jats:sub>2<\/jats:sub>\n                    ]\n                    <jats:sub>3<\/jats:sub>\n                    , which in\u2005situ generates Pd complex(es) highly reactive to racemization and the NaOAc\u2010mediated acceleration of racemization, are notable breakthroughs. Consequently, the DKR of racemic allylic esters can be completed in a few hours at 40\u2009\u00b0C in most cases, yielding optically active allylic alcohols (93\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    to &gt;99\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    ) in 58\u201391\u2009% isolated yields with minimal side reactions.\n                  <\/jats:p>","DOI":"10.1002\/chem.202404406","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T07:45:18Z","timestamp":1741851918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lipase\u2010Palladium Co\u2010Catalyzed Dynamic Kinetic Resolution of Racemic Allylic Esters"],"prefix":"10.1002","volume":"31","author":[{"given":"Masato","family":"Oono","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Osaka University  1-6 Yamadaoka, Suita Osaka 565-0871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Yamada","sequence":"additional","affiliation":[{"name":"Research Foundation Itsuu Laboratory C1232 Kanagawa Science Park R &amp; D Building  3-2-1 Sakado Takatsu-ku Kawasaki, Kanagawa 213-0012 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-3469","authenticated-orcid":false,"given":"Masanari","family":"Kimura","sequence":"additional","affiliation":[{"name":"Graduate School of Integrated Science and Technology Nagasaki University  1-14 Bunkyo-machi Nagasaki 852-8521 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2251-4665","authenticated-orcid":false,"given":"Kyohei","family":"Kanomata","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Osaka University  1-6 Yamadaoka, Suita Osaka 565-0871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9149-8745","authenticated-orcid":false,"given":"Shuji","family":"Akai","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Osaka University  1-6 Yamadaoka, Suita Osaka 565-0871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"For recent general reviews on DKR:Science of Synthesis: Dynamic Kinetic Resolution(DKR)and Dynamic Kinetic Asymmetric Transformations(DYKAT) (Ed.: J.-E. Backvall) Thieme: Stuttgart 2023."},{"key":"e_1_2_9_2_1","unstructured":"For recent reviews on chemoenzymatic DKR:"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.109160"},{"key":"e_1_2_9_4_2","unstructured":"K. Kanomata S. Akai. inScience of Synthesis Dynamic Kinetic Resolution(DKR)and Dynamic Kinetic Asymmetric Transform(DYKAT) (Ed.: J.-E. B\u00e4ckvall) Thieme: Stuttgart 2023 pp.\u2005181\u2013217;"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00454"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.1c00463"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202201035"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/sym13091744"},{"key":"e_1_2_9_9_1","unstructured":"For recent reviews on the asymmetric synthesis of chiralsec-alcohols:"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132238"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CY02409F"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"K. Faber Biotransformations in Organic Chemistry:7th ed. Springer 2018.","DOI":"10.1007\/978-3-319-61590-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar400038g"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202300878"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.140223"},{"key":"e_1_2_9_16_1","unstructured":"\u00a0"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201208988"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503765"},{"key":"e_1_2_9_19_1","unstructured":"\u00a0"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c02703"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202000292"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(96)00136-0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo990956w"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b01400"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00389a064"},{"key":"e_1_2_9_26_1","unstructured":"\u00a0"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.202100203"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1610386"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00043a034"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201600104"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202300575"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201403343"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol302430h"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b03695"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2GC01602H"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC45772A"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201705164"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c02150"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol500456s"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307697"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01489"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01375"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo1011653"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/B400242C"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202404406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202404406","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202404406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:48:05Z","timestamp":1769590085000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202404406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":44,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/chem.202404406"],"URL":"https:\/\/doi.org\/10.1002\/chem.202404406","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,11]]},"assertion":[{"value":"2024-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202404406"}}