{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:04Z","timestamp":1786977484927,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["20\/FFP-P\/8712"],"award-info":[{"award-number":["20\/FFP-P\/8712"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Herein we report the efficient synthesis of \u03b2\u2010aminoketones\n                    <jats:italic>via<\/jats:italic>\n                    addition of a vinyl Grignard reagent into amides followed by trapping of the vinyl ketone intermediate with the magnesium\u2010amide by\u2010product. The reaction was successfully translated from a batch process into continuous flow mode to increase its efficiency, safety and scalability. Different set\u2010ups were evaluated to minimize\/overcome clogging issues arising from magnesium salt precipitates. Ultimately, the resulting \u03b2\u2010aminoketones were obtained in high yields and productivities with residence times of less than 90\u2005seconds at elevated temperatures of 50\u2009\u00b0C. Importantly, the \u03b2\u2010aminoketone products are valuable building blocks that can be unmasked to reactive vinyl ketones\n                    <jats:italic>via<\/jats:italic>\n                    a Cope elimination process.\n                  <\/jats:p>","DOI":"10.1002\/chem.202500014","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T04:24:46Z","timestamp":1738729486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Continuous Flow Synthesis of \u03b2\u2010Aminoketones as Masked Vinyl Ketone Equivalents"],"prefix":"10.1002","volume":"31","author":[{"given":"Ruairi","family":"Bannon","sequence":"first","affiliation":[{"name":"School of Chemistry University College Dublin  Belfield D04 N2E2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-0382","authenticated-orcid":false,"given":"Megan","family":"Smyth","sequence":"additional","affiliation":[{"name":"Technology Department Almac Sciences  Craigavon BT63 5QD U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-0269","authenticated-orcid":false,"given":"Thomas S.","family":"Moody","sequence":"additional","affiliation":[{"name":"Technology Department Almac Sciences  Craigavon BT63 5QD U.K."},{"name":"Arran Chemical Company  Roscommon N37 DN24 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Wharry","sequence":"additional","affiliation":[{"name":"Technology Department Almac Sciences  Craigavon BT63 5QD U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-0053","authenticated-orcid":false,"given":"Philippe M. 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