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We introduce here the catalytic synthesis of hydroquinolines starting from nitroaldehydes, ketones and hydrogen. The reaction is complex and proceeds via multiple selective hydrogenation and condensation steps. The nitroaldehyde is selectively hydrogenated forming an aminoaldehyde, followed by a base\u2010catalyzed <jats:italic>Friedl\u00e4nder<\/jats:italic> synthesis and selective quinoline hydrogenation. The starting materials are inexpensive, simple regarding their structure and diversely available, and the hydroquinoline motif is part of numerous biologically active compounds. A nanostructured earth\u2010abundant metal catalyst mediates our reaction most efficiently.<\/jats:p>","DOI":"10.1002\/chem.202500462","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:14:36Z","timestamp":1741824876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Synthesis of Hydroquinolines from Nitroaldehydes and Ketones by Hydrogenation Sequences and Condensations"],"prefix":"10.1002","volume":"31","author":[{"given":"Christof","family":"Bauer","sequence":"first","affiliation":[{"name":"Inorganic Chemistry II \u2013 Catalyst Design Sustainable Chemistry Centre University of Bayreuth  95440 Bayreuth Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Zareh","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry II \u2013 Catalyst Design Sustainable Chemistry Centre University of Bayreuth  95440 Bayreuth Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"N\u00fc\u00dflein","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry II \u2013 Catalyst Design Sustainable Chemistry Centre University of Bayreuth  95440 Bayreuth Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Frank","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry II \u2013 Catalyst Design Sustainable Chemistry Centre University of Bayreuth  95440 Bayreuth Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Boniface","sequence":"additional","affiliation":[{"name":"Fritz Haber Institute of the Max Planck Society Department of Inorganic Chemistry  14195 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lunkenbein","sequence":"additional","affiliation":[{"name":"Fritz Haber Institute of the Max Planck Society Department of Inorganic Chemistry  14195 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9138-4155","authenticated-orcid":false,"given":"Rhett","family":"Kempe","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry II \u2013 Catalyst Design Sustainable Chemistry Centre University of Bayreuth  95440 Bayreuth Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.ado1246"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05950-8"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06001-y"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm7599"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04516-4"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm5281"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"B. 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