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The Cu<jats:sub>D<\/jats:sub> site with two histidines and an asparagine coordinating to copper has been identified as a potential active site of pMMO. Here, we present a copper cage complex, that assembles this coordination sphere, being a structural mimic of the pMMO. The cage is capable to catalyze aerobic oxidations of organic substrates such as benzylic alcohols to aldehydes and hydroquinones to quinones. This is inspired by the reactivity that is observed for enzymatic active sites possessing copper.<\/jats:p>","DOI":"10.1002\/chem.202500533","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T03:22:17Z","timestamp":1741749737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mimicking the Cu<sub>D<\/sub> Site of pMMO via a Copper Cage\u2010Complex"],"prefix":"10.1002","volume":"31","author":[{"given":"Shunyi","family":"Miao","sequence":"first","affiliation":[{"name":"Institute of Inorganic Chemistry University of Goettingen  Tammannstra\u00dfe 4 37077 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Gerndt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Chemie Humboldt-Universit\u00e4t zu Berlin  Brook-Taylor-Stra\u00dfe 2 12489 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Roemelt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Chemie Humboldt-Universit\u00e4t zu Berlin  Brook-Taylor-Stra\u00dfe 2 12489 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6858-4960","authenticated-orcid":false,"given":"Matthias","family":"Otte","sequence":"additional","affiliation":[{"name":"Institute of Inorganic Chemistry University of Goettingen  Tammannstra\u00dfe 4 37077 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247828"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja202642y"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar020230d"},{"key":"e_1_2_3_4_1","unstructured":"\u00a0"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00624"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00727"},{"key":"e_1_2_3_7_1","unstructured":"\u00a0"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar1001473"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-013118-111529"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03311"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c04082"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm3282"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar700277n"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201209846"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10590-6"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-021-00591-4"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-023-01051-x"},{"key":"e_1_2_3_18_1","unstructured":"\u00a0"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00211C"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC06990C"},{"key":"e_1_2_3_21_1","unstructured":"\u00a0"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic500333p"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.9b00199"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC05441K"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.2c02775"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC02679E"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11928"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00184"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC00437H"},{"key":"e_1_2_3_30_1","author":"Bete S. 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