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Understanding the mechanism of on\u2010surface reactions requires knowledge of the molecular structure and possible organization of reactants into supramolecular assemblies during the reaction. Scanning probe techniques are essential for the unambiguous identification of the products and for determining their electronic and magnetic properties. However, these are generally not capable of imaging the surface at reaction conditions and, therefore, answering some of the key questions about the reaction mechanism. Here, we show that real\u2010time low\u2010energy electron microscopy (LEEM) can monitor the surface processes in real time and provide the necessary complementary mechanistic insights into on\u2010surface reactions. We monitor the intramolecular ring\u2010closure reaction of 1,3,5\u2010tris(7\u2010methyl\u2010\u03b1\u2010carbolin\u20106\u2010yl)benzene on the Au(111) surface and show that it takes place in the 2D molecular gas phase at elevated temperatures. Products condense into separate islands upon cooling, enabling fast and efficient assessment of product yields. This makes LEEM an efficient tool for studying intramolecular chemical reactions.<\/jats:p>","DOI":"10.1002\/chem.202500561","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:57:16Z","timestamp":1739512636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Monitoring On\u2010Surface Chemical Reactions by Low\u2010Energy Electron Microscopy: from Conformation Change to Ring Closure in 2D Molecular Gas"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4727-4776","authenticated-orcid":false,"given":"Pavel","family":"Proch\u00e1zka","sequence":"first","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology Brno University of Technology  Purky\u0148ova 123 612 00 Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-3880","authenticated-orcid":false,"given":"Federico","family":"Frezza","sequence":"additional","affiliation":[{"name":"Institute of Physics Czech Academy of Sciences  Cukrovarnick\u00e1 10 16200 Prague Czech Republic"},{"name":"Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague  B\u0159ehov\u00e1 78\/7 11519 Prague 1 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5499-0199","authenticated-orcid":false,"given":"Ana","family":"S\u00e1nchez\u2010Grande","sequence":"additional","affiliation":[{"name":"Institute of Physics Czech Academy of Sciences  Cukrovarnick\u00e1 10 16200 Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Carrera","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry University of Murcia  Campus of Espinardo Murcia-30100 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Physics Czech Academy of Sciences  Cukrovarnick\u00e1 10 16200 Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-4366","authenticated-orcid":false,"given":"Veronika","family":"Star\u00e1","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology Brno University of Technology  Purky\u0148ova 123 612 00 Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-8434","authenticated-orcid":false,"given":"Anna","family":"Kurowsk\u00e1","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology Brno University of Technology  Purky\u0148ova 123 612 00 Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6717-6305","authenticated-orcid":false,"given":"David","family":"Curiel","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry University of Murcia  Campus of Espinardo Murcia-30100 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5645-8542","authenticated-orcid":false,"given":"Pavel","family":"Jel\u00ednek","sequence":"additional","affiliation":[{"name":"Institute of Physics Czech Academy of Sciences  Cukrovarnick\u00e1 10 16200 Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-8441","authenticated-orcid":false,"given":"Jan","family":"\u010cechal","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology Brno University of Technology  Purky\u0148ova 123 612 00 Brno Czech Republic"},{"name":"Institute of Physical Engineering Brno University of Technology  Technick\u00e1 2896\/2 616 69 Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03766"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03513"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00601"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0392-9"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-648X\/ac8a7f"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c10088"},{"key":"e_1_2_3_7_1","first-page":"53","volume":"15","author":"Zhao Y.","year":"2023","journal-title":". 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