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In this oxidation\u2010based ketone formation reaction, molecular oxygen complexes with the substrate, which is subsequently photoexcited to generate a charge transfer (CT) state. This CT state facilitates energy transfer with molecular oxygen, producing singlet oxygen, which facilitates hydrogen atom process and promotes the subsequent cleavage of the carbon\u2013carbon bond, ultimately leading to the formation of aryl ketone compounds. 48 aryl ketone compounds and pharmaceutical derivatives were synthesized using this method. A notable feature of this reaction is its catalyst\u2010free, additive\u2010free, and transition metals\u2010free nature combined with green, mild, and environmentally friendly reaction conditions enabling high yields.<\/jats:p>","DOI":"10.1002\/chem.202500937","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T03:15:53Z","timestamp":1745378153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Visible Light\u2010Induced C\u2500C Bond Cleavage for the Construction of Ketone Using Molecular Oxygen"],"prefix":"10.1002","volume":"31","author":[{"given":"Bin","family":"Sun","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of Technology  Hangzhou Zhejiang 310014 China"},{"name":"Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical 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