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Herein, we pioneered bovine serum albumin (BSA) as a natural clusterization\u2010triggered emission (CTE) probe for one\u2010step detection of chlorpromazine hydrochloride (CPZ) and perphenazine (PPZ). The unique CTE property of BSA displayed concentration\u2010dependent quenching with CPZ and PPZ. Moreover, the quenching effect achieved balance within 5\u00a0minutes and maintained stability for more than 30\u00a0minutes. Based on these advantages, the proposed detection platform showed rapid response, operational simplicity, visual signal readout, wide detection range, ultra\u2010low detection limits, compared with other methods. Moreover, the assay method exhibited excellent selectivity, facilitating satisfactory reliability for the real sample assay. Thermodynamic analyses revealed distinct interaction mechanisms between BSA and antipsychotics, both inducing static quenching by suppressing clusterization\u2010induced electron transitions. Overall, this research not only develops a novel assay method for CPZ and PPZ, but also broadens the application potential of the CTE effect in natural biomacromolecules. As the first demonstration of natural CTE probes for antipsychotic detection, this work opens new frontiers for sustainable analytical technologies by circumventing synthetic probe complexities and leveraging inherent biorecognition.<\/jats:p>","DOI":"10.1002\/chem.202500950","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T22:24:56Z","timestamp":1745015096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Specific Quenching of Natural Clusterization\u2010Triggered Emission Probes for Rapid Fluorescent Detection of Antipsychotics"],"prefix":"10.1002","volume":"31","author":[{"given":"Jiying","family":"Song","sequence":"first","affiliation":[{"name":"College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University  700 Changcheng Road Qingdao Shandong 266109 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University  700 Changcheng Road Qingdao Shandong 266109 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunge","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University  700 Changcheng Road Qingdao Shandong 266109 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junde","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital, Qingdao Agricultural University  700 Changcheng Road Qingdao Shandong 266109 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-0718","authenticated-orcid":false,"given":"Lei","family":"Han","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University  700 Changcheng Road Qingdao Shandong 266109 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-018-0206-4"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2024.2367672"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-023-01693-8"},{"key":"e_1_2_8_4_1","volume":"16","author":"Hower M. 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