{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:44:31Z","timestamp":1767422671056,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22064020","22364022","22174125"],"award-info":[{"award-number":["22064020","22364022","22174125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202201AT070029"],"award-info":[{"award-number":["202201AT070029"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this work, a reduced homochiral porous organic cage (RCC2\u2010<jats:italic>S<\/jats:italic>)\u2010based chiral stationary phase (CSP), RCC2\u2010<jats:italic>S<\/jats:italic>@SiO<jats:sub>2<\/jats:sub>\u2010SH, was prepared by bonding RCC2\u2010<jats:italic>S<\/jats:italic> on thiolated silica (SiO<jats:sub>2<\/jats:sub>\u2010SH) via a thiol\u2010ene click reaction. The CSP (RCC2\u2010<jats:italic>S<\/jats:italic>@SiO<jats:sub>2<\/jats:sub>\u2010SH) showed excellent enantioseparation in both normal\u2010phase HPLC (NP\u2010HPLC) and reversed\u2010phase HPLC (RP\u2010HPLC) modes, effectively separating various chiral compounds, including alcohols, esters, ketones, amines, imidazoles, epoxides, and organic acids. As a result, 12 racemates were enantioseparated under NP\u2010HPLC, and 17 racemates were enantioseparated under RP\u2010HPLC. The CSP also exhibited good complementarity in chiral separation with commercial Chiralpak AD\u2010H, Chiralcel OD\u2010H, and the previously reported chiral POC CC19\u2010<jats:italic>R<\/jats:italic> columns, successfully separating some racemates that remained unresolved or poorly resolved on these three columns. Additionally, the fabricated RCC2\u2010<jats:italic>S<\/jats:italic>@SiO<jats:sub>2<\/jats:sub>\u2010SH packed column demonstrated good reproducibility and stability. The relative standard deviations (RSDs) of retention time and resolution value were less than 0.5% and 1.5%, respectively, after the column had been subjected to hundreds of injections. This work indicates that chiral porous organic cages have great potential for the separation of enantiomers in HPLC.<\/jats:p>","DOI":"10.1002\/chem.202500977","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T22:09:27Z","timestamp":1745273367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preparation of a Homochiral Porous Organic Cage RCC2\u2010<i>S<\/i>\u2010Bonded Silica as a Stationary Phase for High\u2010Performance Liquid Chromatography Enantioseparation"],"prefix":"10.1002","volume":"31","author":[{"given":"Hua\u2010Can","family":"Zhang","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming 650500 P.R. 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