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The present work examines synthetic variables including the effect of increasing Europium concentration during QDs\u2019 synthesis and the use of different coating agents (citrate versus APTES) to improve the QDs' colloidal stability and ameliorate their cytotoxic behavior. All samples were subjected to structural and morphological characterizations via Fourier Transform infrared (FT\u2010IR) spectroscopy, UV\u2013Visible (UV\u2010Vis) spectrophotometry, Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS). Subsequently, biological evaluation of all the synthesized samples of bare and APTES coated CdSe:Eu QDs was conducted on epithelial HaCaT and breast cancer MCF\u20107. Wound healing assays were conducted to assess cytotoxicity and cell migration under QD treatment. Results showed that both coated and uncoated QDs influenced wound closure rates in a concentration\u2010 and time\u2010dependent manner. Finally, fluorescence microscopy revealed significant green luminescence of CdSe:Eu quantum dots (QDs) in both HaCaT and MCF\u20107 cell lines, indicating efficient cellular uptake. The internalization of QDs was influenced by their surface properties and charge, suggesting an endocytic uptake pathway.<\/jats:p>","DOI":"10.1002\/chem.202500986","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T22:24:40Z","timestamp":1746570280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dextran\u2010Assisted Biomimetic Fabrication of CdSe:Eu QDs With Enhanced Biocompatibility and Stability"],"prefix":"10.1002","volume":"31","author":[{"given":"Myrto","family":"Margariti","sequence":"first","affiliation":[{"name":"Inorganic Chemistry Laboratory, Department of Chemistry National and Kapodistrian University of Athens Zografou 15771 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Roussaki","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Laboratory, Department of Chemistry National and Kapodistrian University of Athens Zografou 15771 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Sakellis","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience and Nanotechnology National Center of Scientific Research \u201cDemokritos\u201d Agia Paraskevi 15341 Greece"},{"name":"Section of Condensed Matter Physics, Department of Physics National and Kapodistrian University of Athens Athens 15784 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Boukos","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience and Nanotechnology National Center of Scientific Research \u201cDemokritos\u201d Agia Paraskevi 15341 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Theodosiou","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Laboratory, Department of Chemistry National and Kapodistrian University of Athens Zografou 15771 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoleta","family":"Kostopoulou","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Laboratory, Department of Chemistry National and Kapodistrian University of Athens Zografou 15771 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-7881","authenticated-orcid":false,"given":"Eleni K.","family":"Efthimiadou","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Laboratory, Department of Chemistry National and Kapodistrian University of Athens Zografou 15771 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"crossref","unstructured":"K. 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