{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:02:58Z","timestamp":1783040578897,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFS2123"],"award-info":[{"award-number":["JPMJFS2123"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007684","name":"Asahi Glass Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Metal naphthalocyanine (MNc) is one of the most promising near\u2010infrared (NIR) dyes as a photosensitizer for phototheranostics, combining photoacoustic imaging (PAI) and photothermal therapy (PTT). However, the extremely low solubility of MNc has limited its practical application as a theranostic agent. In this research, we synthesized NiNc precursors (\n                    <jats:bold>ox\u2010NiNc<\/jats:bold>\n                    ) having two alkoxy groups on the \u03b1\u2010carbons of the diagonal pyrroles with significantly improved solubility. We also prepared an amphiphilic derivative,\n                    <jats:bold>ox\u2010NiNc\u2010PEG<\/jats:bold>\n                    , and investigated its conversion to NiNc through reductive aromatization. We demonstrated that\n                    <jats:bold>ox\u2010NiNc\u2010PEG<\/jats:bold>\n                    was efficiently converted to NiNc in cancer cells with elevated glutathione levels, resulting in enhanced photoacoustic signals and increased phototoxicity based on photothermal conversion under NIR light irradiation. The target\u2010oriented reductive aromatization in response to the reducing environment in cancer cells offers a critical strategy for developing PAI\/PTT theranostic agents.\n                  <\/jats:p>","DOI":"10.1002\/chem.202501346","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:30:38Z","timestamp":1748565038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Reductively Activatable Phototheranostic Agent Based on a Water\u2010Soluble Nickel Naphthalocyanine Precursor"],"prefix":"10.1002","volume":"31","author":[{"given":"Kohei","family":"Nogita","sequence":"first","affiliation":[{"name":"Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering Kyoto University  Katsura, Nishikyo\u2010ku Kyoto 615\u20108510 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