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These compounds were synthesized via a three\u2010step reaction starting from various glycidyl ethers, purified by fractional distillation and drying, and obtained with overall isolated yields of at least 60%. The ratio of isomer configurations (<jats:italic>E:E:Z:Z<\/jats:italic>) varied based on substituents R<jats:sub>1<\/jats:sub> and R<jats:sub>2<\/jats:sub>. Thermophysical properties, including density, refractive index (RI), and viscosity, were evaluated at temperatures of 293.15 to 333.15 and 353.15\u00a0K. CO<jats:sub>2<\/jats:sub> absorption capacity (Henry's constants) of compound [F, A, A] was assessed at temperatures of 303.15, 318.15, 333.15, and 348.15\u00a0K under CO<jats:sub>2<\/jats:sub> pressures from 2 to 10 atm. Density, viscosity, vapor pressure, enthalpy of vaporization, and dipole moment were also calculated for each compound. Moreover, the nonsymmetric alkenes\u2019 C\u00a0\u2550\u00a0C double bond was shown to readily react with thiols via thiol\u2010ene coupling. The resulting thioether linkage exhibits high stability under physiological conditions, making these compounds promising intermediates for synthesizing more complex glycerol\u2010based molecules.<\/jats:p>","DOI":"10.1002\/chem.202501406","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:26:15Z","timestamp":1753773975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis and Properties of Novel Glycerol\u2010Derived Liquids with Dual Functional Groups: Nonsymmetric (<i>E\/Z<\/i>)\u2010Isomeric Mixtures of 1,3\u2010Diether\u20102\u2010Alkenes"],"prefix":"10.1002","volume":"31","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemical &amp; Biological Engineering The University of Alabama  Tuscaloosa AL 35487\u20100203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Iddrisu","sequence":"additional","affiliation":[{"name":"Department of Chemical &amp; Biological Engineering The University of Alabama  Tuscaloosa AL 35487\u20100203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-7957","authenticated-orcid":false,"given":"Zahra Sekhavat","family":"Pour","sequence":"additional","affiliation":[{"name":"Department of Chemical &amp; Biological Engineering The University of Alabama  Tuscaloosa AL 35487\u20100203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-7102","authenticated-orcid":false,"given":"Sudhir","family":"Ravula","sequence":"additional","affiliation":[{"name":"Department of Chemical &amp; Biological Engineering The University of Alabama  Tuscaloosa AL 35487\u20100203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4218-1570","authenticated-orcid":false,"given":"Tibor","family":"Szilv\u00e1si","sequence":"additional","affiliation":[{"name":"Department of Chemical &amp; Biological Engineering The University of Alabama  Tuscaloosa AL 35487\u20100203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-2145","authenticated-orcid":false,"given":"Jason E.","family":"Bara","sequence":"additional","affiliation":[{"name":"Department of Chemical &amp; Biological Engineering The University of Alabama  Tuscaloosa AL 35487\u20100203 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/B918763B"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2024.101656"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC03662A"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2013.06.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2013.06.035"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SE01647H"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.9b00411"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/B710561D"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2012.08.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpowsour.2024.235535"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2014.02.033"},{"key":"e_1_2_8_12_1","first-page":"778","volume":"5","author":"Zaffalon P. 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