{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:58:20Z","timestamp":1785455900142,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["02(0254)\/16\/EMR\u2010II"],"award-info":[{"award-number":["02(0254)\/16\/EMR\u2010II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An unprecedented organocatalytic enantioselective methodology has been unlocked to access oxindole\u2010fused spiro[furo[2,3\u2010\n                    <jats:italic>d<\/jats:italic>\n                    ]pyrimidines] with high bond efficiency (two new C\u2500C bonds and one C\u2500O bond) and two contiguous stereocenters via Cascade Michael\u2010Cyclopropanation\u2010Rearrangement. A series of spiro[furo[2,3\u2010\n                    <jats:italic>d<\/jats:italic>\n                    ]pyrimidines] has been synthesized in excellent yield (up to 90%) and stereoselectivity (dr up to 99:1, er up to 97:3) from 3\u2010chlorooxindoles and 5\u2010alkylidene barbituric acids at room temperature.\n                    <jats:sup>1<\/jats:sup>\n                    H NMR and HRMS studies have been conducted to define the reaction pathway.\n                  <\/jats:p>","DOI":"10.1002\/chem.202501748","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:26:35Z","timestamp":1760595995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Asymmetric Cascade Michael\u2010Cyclopropanation\u2010Rearrangement to Spiro[Furo[2,3\u2010\n                    <i>d<\/i>\n                    ]Pyrimidines]"],"prefix":"10.1002","volume":"32","author":[{"given":"Manju","family":"Devi","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Delhi  Hauz Khas New Delhi 110016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmuddin","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Delhi  Hauz Khas New Delhi 110016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Delhi  Hauz Khas New Delhi 110016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112801"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2725(08)60222-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.10.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/501021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2016.05.005"},{"key":"e_1_2_8_6_1","first-page":"1454","volume":"53","author":"Sambavekar P.","year":"2014","journal-title":"Indian J. Chem."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106390"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300521"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105336"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.05.038"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200900339"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01434"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.04.054"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00722"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15119c"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.06.081"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b03694"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2010.10.041"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.11.057"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1081\/SCC-200034786"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.201190031"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-011-9302-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2011.32.9.3382"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.5012\/jkcs.2011.55.6.940"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.201500257"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13738-020-02041-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2013.06.030"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3184\/174751916X14568468874639"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207311316060003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4QO00535J"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/M1317"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM-14-13141"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.18.162"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201700487"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC01509D"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA01086G"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b03004"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0QO01085E"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0351910"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b01639"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1731-2703"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2165\/11597630-000000000-00000"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.08.039"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja036878i"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200701098"},{"key":"e_1_2_8_46_1","first-page":"1483","volume":"11","author":"Takenaka K.","year":"2009","journal-title":"Lett"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201300019"},{"key":"e_1_2_8_48_1","unstructured":"Deposition numbers 2392587 (for 3a) and 2446594 (for 3b) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe service.http:\/\/www.ccdc.cam.ac.uk\/structures."},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5QO00092K"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201903330"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b04792"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB01903H"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO01091K"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202501748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202501748","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202501748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:08:09Z","timestamp":1785452889000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202501748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":53,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2026,7,25]]}},"alternative-id":["10.1002\/chem.202501748"],"URL":"https:\/\/doi.org\/10.1002\/chem.202501748","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"2025-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01748"}}