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The molecular functions of pillararenes can be easily expanded through the introduction of different functional groups into the side chain. For example, polyethylene glycol (PEG) which has good biocompatibility and water solubility can be used to construct PEG\u2010functionalized amphiphilic pillararenes. These PEG\u2010functionalized amphiphilic pillararenes can be used to construct the nanocarriers with good water solubility and excellent biocompatibility through their self\u2010assembly to deliver hydrophobic drugs. Although there are many reviews introducing the application of amphiphilic pillararenes in drug delivery, there are still no comprehensive articles summarizing such type of pillararenes. In this paper, based on their functional characteristics, the applications of PEG\u2010functionalized amphiphilic pillararene in drug delivery systems have been summarized. We focused on the relationship between their molecular design and functional application, providing reasonable guidance for the structural design of amphiphilic pillararenes.<\/jats:p>","DOI":"10.1002\/chem.202502117","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T11:46:31Z","timestamp":1754480791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Application of PEG\u2010functionalized Amphiphilic Pillararene in Drug Delivery Systems"],"prefix":"10.1002","volume":"31","author":[{"given":"Long","family":"Yao","sequence":"first","affiliation":[{"name":"Analysis and Testing Center Nantong University  No.9 Seyuan Road, Chongchuan District Nantong Jiangsu 226019 P. R. 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