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Building on this activation mode, we have developed an electrophotocatalytic method for the direct amidation of aldehydes, utilizing electricity and protons as oxidants and light to generate chlorine radicals for hydrogen atom transfer (HAT). This sustainable approach is compatible with a wide range of aldehydes and nitrogen\u2010based nucleophiles, performing efficiently under batch conditions and demonstrating scalability with flow technology. The mild reaction conditions, adequate functional group tolerance, and versatility make this EPC protocol particularly suitable for C\u2500N bond formation, enabling functionalization of diverse organic compounds and facilitating late\u2010stage modifications in drug development.<\/jats:p>","DOI":"10.1002\/chem.202502237","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:51:30Z","timestamp":1754916690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oxidant\u2010Free Amidation of Aldehydes Enabled by Electrophotocatalysis"],"prefix":"10.1002","volume":"31","author":[{"given":"Dimitris I.","family":"Ioannou","sequence":"first","affiliation":[{"name":"Flow Chemistry Group van \u2019t Hoff Institute for Molecular Sciences (HIMS) University of Amsterdam  Science Park 904 Amsterdam 1098 XH The Netherlands"},{"name":"Supramolecular and Homogeneous Catalysis Group van \u2019t Hoff Institute for Molecular Sciences (HIMS) University of Amsterdam  Science Park 904 Amsterdam 1098 XH The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bombonato","sequence":"additional","affiliation":[{"name":"Flow Chemistry Group van \u2019t Hoff Institute for Molecular Sciences (HIMS) University of Amsterdam  Science Park 904 Amsterdam 1098 XH The Netherlands"},{"name":"Department of Chemistry \u201cGiacomo Ciamician\u201d Universit\u00e0 di Bologna  Via Selmi, 2 Bologna 40126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Sanramat","sequence":"additional","affiliation":[{"name":"Flow Chemistry Group van \u2019t Hoff Institute for Molecular Sciences (HIMS) University of Amsterdam  Science Park 904 Amsterdam 1098 XH The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost N. 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