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All compounds were fully characterized by elemental analysis, mass spectrometry, powder X\u2010ray diffractometry, and a range of spectroscopic techniques (\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, FT\u2010IR, and UV\u2013visible diffuse reflectance). The crystal and molecular structures were elucidated via single\u2010crystal X\u2010ray diffraction, and their supramolecular features were explored through Hirshfeld surface analysis. The\n                    <jats:sup>57<\/jats:sup>\n                    Fe M\u00f6ssbauer and magnetic SQUID measurements confirmed the high\u2010spin nature of the Fe\n                    <jats:sup>II<\/jats:sup>\n                    complex\n                    <jats:bold>1<\/jats:bold>\n                    . In the three human cancer cell lines, most metal complexes are somewhat more cytotoxic than the inactive ligands, with Co(II) complexes\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    being the most potent in two of the cell lines (with\n                    <jats:italic>\n                      IC\n                      <jats:sub>50<\/jats:sub>\n                    <\/jats:italic>\n                    values in the two\u2010digit micromolar range). Overall, this study highlights how blending tetrazole\/triazole\/pyrazole ligands with transition metals can lead to coordination compounds with potential in anticancer research, as a proof of concept. These results add valuable insight to the expanding field of metal\u2010based therapeutics and could help guide the development of next\u2010generation, more effective agents.\n                  <\/jats:p>","DOI":"10.1002\/chem.202502238","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:52:58Z","timestamp":1768398778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Coordination Complexes and Polymers of Novel Hybrid Tetrazole\u2010Triazole\u2010Pyrazole Ligands: Synthesis, Structural Characterization, and Biological Evaluation"],"prefix":"10.1002","volume":"32","author":[{"given":"Yousra","family":"Bahjou","sequence":"first","affiliation":[{"name":"LCAE Department of Chemistry Faculty of Science University Mohamed I  Oujda Morocco"},{"name":"Institute of Condensed Matter and Nanosciences Molecular Chemistry Materials and Catalysis (IMCN\/MOST) Universit\u00e9 catholique de Louvain  Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3959-1088","authenticated-orcid":false,"given":"Youssef","family":"Draoui","sequence":"additional","affiliation":[{"name":"LCAE Department of Chemistry Faculty of Science University Mohamed I  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5062-6904","authenticated-orcid":false,"given":"Smaail","family":"Radi","sequence":"additional","affiliation":[{"name":"LCAE Department of Chemistry Faculty of Science University Mohamed I  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-4217","authenticated-orcid":false,"given":"Koen","family":"Robeyns","sequence":"additional","affiliation":[{"name":"Institute of Condensed Matter and Nanosciences Molecular Chemistry Materials and Catalysis (IMCN\/MOST) Universit\u00e9 catholique de Louvain  Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Condensed Matter and Nanosciences Molecular Chemistry Materials and Catalysis (IMCN\/MOST) Universit\u00e9 catholique de Louvain  Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-5173","authenticated-orcid":false,"given":"Haralampos N.","family":"Miras","sequence":"additional","affiliation":[{"name":"School of Chemistry Joseph Black Building University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7019-4635","authenticated-orcid":false,"given":"Marilena","family":"Ferbinteanu","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Department Faculty of Chemistry University of Bucharest  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8782-7988","authenticated-orcid":false,"given":"Aurelian","family":"Rotaru","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science &amp; 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