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To date, no eyedrop formulation has been clinically approved for the treatment of ocular fundus diseases. Eyedrops reach the posterior segment via two primary routes: the corneal route and the conjunctival routes, the latter comprising the conjunctival\u2013vasculature route and the conjunctival\u2013scleral route. This review summarizes recent advances in topical eyedrop therapies for ocular fundus diseases, with a focus on their delivery routes and the mechanisms by which they reach the posterior segment of eye. The cell\u2010penetrating homing peptides and lipid nanoparticle\u2010encapsulated eyedrops primarily reach the posterior segment via the corneal route; cell\u2010penetrating peptides and PepT\u20101\u2010targeting ligands mainly utilize the conjunctival route; whereas chitosan nanoparticles, polymeric micelles, and supramolecular peptide\u2010based eyedrops can access the posterior segment via both routes. By systematically clarifying the pathways and mechanisms by which eyedrops formulations traverse ocular barriers, this review aims to provide a rational foundation for future research and development in posterior segment drug delivery.<\/jats:p>","DOI":"10.1002\/chem.202502324","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:26:40Z","timestamp":1763965600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Delivery Routes of Topical Eyedrops Reaching the Posterior Segment of the Eye\u2010Recent Advances"],"prefix":"10.1002","volume":"31","author":[{"given":"Yuhong","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 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