{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T08:42:38Z","timestamp":1786178558907,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201020\u2010CE07\u20100009"],"award-info":[{"award-number":["ANR\u201020\u2010CE07\u20100009"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["StG\u2010638712,'aLzINK'"],"award-info":[{"award-number":["StG\u2010638712,'aLzINK'"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    ROS production due to Cu(amyloid\u2010\u03b2) redox cycling is proposed to contribute to the oxidative stress observed in Alzheimer's disease brains. We previously reported on a nitrogen and sulfur\u2010containing ligand,\n                    <jats:bold>L<\/jats:bold>\n                    , able to arrest Cu(A\u03b2)\u2010induced ROS production [\n                    <jats:italic>Chem. Eur. J<\/jats:italic>\n                    .\n                    <jats:bold>2023<\/jats:bold>\n                    ,\n                    <jats:italic>29<\/jats:italic>\n                    ,]. In the present study, the intricate mechanism by which\n                    <jats:bold>L<\/jats:bold>\n                    maintains its protective activity in the presence of Zn, an abundant endogenous metal ion found in the synaptic cleft, is disentangled with the use of complementary spectroscopic and analytical investigations. This mechanism, which we refer to as kinetic Cu(I) shunt, relies on a faster Cu(I) than Zn transfer from Cu,Zn(A\u03b2) to\n                    <jats:bold>L<\/jats:bold>\n                    , followed by a fast re\u2010oxidation of Cu(I)(\n                    <jats:bold>L<\/jats:bold>\n                    ) to Cu(II)(\n                    <jats:bold>L<\/jats:bold>\n                    ), which is redox\u2010inert (i.e. resistant against reduction from ascorbate). This study hence provides new insights into the kinetic involvement of Cu(I) ions in the inhibition of Cu(A\u03b2)\u2010associated ROS production in presence of Zn.\n                  <\/jats:p>","DOI":"10.1002\/chem.202502352","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T06:47:59Z","timestamp":1766558879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cu(I) Is a Game Changer in the Arrest of Cu(A\u03b2)\u2010Induced ROS Production in the Presence of Competing Zn(II) Ions"],"prefix":"10.1002","volume":"32","author":[{"given":"Marielle","family":"Drommi","sequence":"first","affiliation":[{"name":"Laboratoire De Chimie de Coordination CNRS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyangwi Patrick","family":"Malikidogo","sequence":"additional","affiliation":[{"name":"Laboratoire De Chimie de Coordination CNRS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Atri\u00e1n\u2010Blasco","sequence":"additional","affiliation":[{"name":"Laboratoire De Chimie de Coordination CNRS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charl\u00e8ne","family":"Esmieu","sequence":"additional","affiliation":[{"name":"Laboratoire De Chimie de Coordination CNRS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-0239","authenticated-orcid":false,"given":"Christelle","family":"Hureau","sequence":"additional","affiliation":[{"name":"Laboratoire De Chimie de Coordination CNRS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"M.Prince A.Wimo M.Guerchet G.\u2010C.Ali Y.\u2010T.Wu andM.Prina World Alzheimer Report 2015.The Global Impact of Dementia. An Analysis of Prevalence Incidence Cost and Trends 2015."},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"2023 Alzheimer's disease facts and figures Alzheimers Dementia2023 19 1598\u20131695.","DOI":"10.1002\/alz.13016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb400080f"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"J.HardyandG.Higgins Alzheimer's disease: the amyloid cascade hypothesis Science 256(1992):184\u2013185.","DOI":"10.1126\/science.1566067"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.11.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u2010510X(98)00092\u20106"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2005.09.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0272151"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf6707"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.037"},{"key":"e_1_2_7_15_1","first-page":"121","article-title":"Current Understanding of Metal\u2010dependent Amyloid\u2010\u03b2 Aggregation and Toxicity RSC","volume":"4","author":"Yi Y.","year":"2023","journal-title":"Chemistry & Biology"},{"key":"e_1_2_7_16_1","first-page":"1","volume-title":"Metal Ions and Complexes in Alzheimer's Disease: From Fundamental to Therapeutic Perspectives","author":"Hureau C.","year":"2019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00443K"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/9781839162732-00170"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101619"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.08.014"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b00740"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775\u2010009\u20100570\u20100"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.10.014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00138"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00248"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216684"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202203667"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.9b00995"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201801520"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.3c02693"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00138A"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775\u2010011\u20100797\u20104"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CB00052D"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.01.016"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc38236a"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7DT01344B"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6DT02308H"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201801387"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111692"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.202100079"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27227903"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101327"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.5802\/crchim.255"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3dt32857k"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2DT03284H"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2024.112480"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/dt9840000673"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277\u20105387(99)00254\u20105"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b04979"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00001C"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac302629u"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201102746"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4mt00016a"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi701355j"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00831"},{"key":"e_1_2_7_56_1","volume-title":"Standard Potentials in Aqueous Solution Routledge","author":"Bertocci U.","year":"1985"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2018.04.007"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.03.011"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1107\/S090904950904919X"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.015"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c03407"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b01733"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201802759"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707109200"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-010-0729-8"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15122719"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jchemed.7b00361"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.013"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202502352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202502352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202502352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T08:01:21Z","timestamp":1786176081000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202502352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":67,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1002\/chem.202502352"],"URL":"https:\/\/doi.org\/10.1002\/chem.202502352","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02352"}}