{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:15:43Z","timestamp":1792444543933,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"65","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2025,11,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The optically active 3\u2010aryl\u20103\u2010hydroxy\u20102\u2010oxindole skeleton is a promising pharmacophore in drug design and has led to the development of metal\u2010catalyzed asymmetric reactions using designed chiral ligands for synthesizing 3\u2010aryl\u20103\u2010hydroxy\u20102\u2010oxindoles from isatins (2,3\u2010oxindoles), 3\u2010aryl\u20102\u2010oxindoles, and \u03b1\u2010ketoamides. Although the arylation of isatins is vital for convergent synthesis, most studies have used\n                    <jats:italic>N<\/jats:italic>\n                    \u2010protected isatins, requiring the removal of protecting groups to obtain the desired bioactive products. Despite limited success in the direct high\u2010enantioselective arylation of unprotected isatins (NH isatins), such arylation holds significant potential for improving atomic and synthetic efficiencies. In aqueous media, cyclodextrins (CDs) with hydrophobic and chiral cavities can selectively include organic compounds, making them potential nanoreactors for asymmetric reactions. In this study, imidazolium salts bearing a \u00a0\u03b3\u2010CD were applied as\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heterocyclic carbene (NHC) ligands for the Rh\u2010catalyzed asymmetric arylation of NH isatins in environmentally benign aqueous ethanol. The arylation was successfully achieved in high yield and enantioselectivity using our \u03b3\u2010CD\u2013NHC\u2013Rh catalyst. This suggests that the arylation proceeds in the \u03b3\u2010CD cavity (host) through the self\u2010inclusion of NHC\u2500Rh complex intermediates (guests). These bio\u2010inspired transition metal catalysts based on host\u2013guest linkage systems are expected to contribute significantly to the development of efficient organic synthesis reactions with high enantioselectivity.\n                  <\/jats:p>","DOI":"10.1002\/chem.202502481","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:43:04Z","timestamp":1761108184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u03b3\u2010Cyclodextrin\u2013Imidazolium Salt\u2010Based Bioinspired Nanoreactor: Enantioselective Rhodium\u2010Catalyzed Arylation of Unprotected Isatin with Arylboronic Acids"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-3484","authenticated-orcid":false,"given":"Susumu","family":"Tsuda","sequence":"first","affiliation":[{"name":"Department of Chemistry Osaka Dental University  Hirakata Osaka 573\u20131121 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