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The electrolyte must ensure efficient CO\n                    <jats:sub>2<\/jats:sub>\n                    reduction while remaining compatible with microbial growth. We investigated various electrolytes for coupling CO\n                    <jats:sub>2<\/jats:sub>\n                    electroreduction to formate with formate fermentation by\n                    <jats:italic>Methylorubrum\u00a0extorquens<\/jats:italic>\n                    TK\u00a00001. Electrolyte performance was evaluated by formate production and microbial growth. A phosphate\u2010based buffer demonstrated the best overall compatibility. Optimal microbial growth occurred at 0.1\u00a0mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    KPi, with tolerance of up to 111\u00a0mmol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    formate. Continuous CO\n                    <jats:sub>2<\/jats:sub>\n                    electrolysis in 1.0\u00a0mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    KPi produced 2.0\u00a0mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    formate in 48 h. Formate fermentation with\n                    <jats:italic>M.\u00a0extorquens<\/jats:italic>\n                    showed biomass yield of 107\u00a0mg CDW g\n                    <jats:sub>formate<\/jats:sub>\n                    <jats:sup>\u22121<\/jats:sup>\n                    and a growth rate of 0.10 h\n                    <jats:sup>\u22121<\/jats:sup>\n                    . These results highlight the crucial role of buffer composition and concentration in balancing efficient CO\n                    <jats:sub>2<\/jats:sub>\n                    electroreduction with stable fermentation. Optimizing this electrochemical\u2013biological interface enables direct utilization of CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010derived formate as a substrate for sustainable microbial production, offering a promising scalable route for industrial biotechnology.\n                  <\/jats:p>","DOI":"10.1002\/chem.202502658","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T15:12:06Z","timestamp":1766589126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Electrocatalytic CO\n                    <sub>2<\/sub>\n                    Reduction Coupled to Formate Fermentation: An Electro\u2010Bio Cascade Approach in Biocompatible Electrolytes"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-6447","authenticated-orcid":false,"given":"Luciana","family":"Vieira","sequence":"first","affiliation":[{"name":"BioCat Branch for Bio, Electro and Chemocatalysis Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB)  Straubing Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0509-5051","authenticated-orcid":false,"given":"Jonathan Thomas","family":"Fabarius","sequence":"additional","affiliation":[{"name":"BioCat Branch for Bio, Electro and Chemocatalysis Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB)  Straubing Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Rizzo","family":"Piton","sequence":"additional","affiliation":[{"name":"BioCat Branch for Bio, Electro and Chemocatalysis Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB)  Straubing Germany"},{"name":"TUM Campus Straubing For Biotechnology and Sustainability Technical University of Munich  Straubing Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-4636","authenticated-orcid":false,"given":"Barbara","family":"Bohlen","sequence":"additional","affiliation":[{"name":"BioCat Branch for Bio, Electro and Chemocatalysis Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB)  Straubing Germany"},{"name":"TUM Campus Straubing For Biotechnology and Sustainability Technical University of Munich  Straubing Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjai","family":"Pangotra","sequence":"additional","affiliation":[{"name":"BioCat Branch for Bio, Electro and Chemocatalysis Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB)  Straubing 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