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The reaction of azachalcone with cyclopentadiene in the presence of\n                    <jats:bold>PQXlac<\/jats:bold>\n                    (1000mer, 1 mol% monomer unit) and Cu(NO\n                    <jats:sub>3<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    (1 mol% Cu) proceeded at 5\u00a0\u00b0C in good yield with high enantioselectivity up to 99% ee. The utilization of the corresponding oligomers shorter than 10mer resulted in low chemical yield with low enantioselectivity, suggesting that a tight helical structure is essential for the formation of an effective catalyst. A comparison of the random and block copolymer of\n                    <jats:bold>PQXlac<\/jats:bold>\n                    and\n                    <jats:bold>PQXteg<\/jats:bold>\n                    , which has achiral tetra(ethylene glycol) side chains, indicated that block copolymer, in which the carboxylate groups are more densely packed, showed higher chemical yields along with higher enantioselectivity. These results suggest that the active catalyst has a copper dicarboxylate structure in which two carboxylate groups on every other monomer unit coordinate to the Cu center to form an effective chiral reaction environment.\n                  <\/jats:p>","DOI":"10.1002\/chem.202502697","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T06:45:57Z","timestamp":1761115557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Helical Polymer\u2010Based Polycarboxylate as Chiral Ligands in Cu\u2010Catalyzed Enantioselective Diels\u2013Alder Reaction in Water"],"prefix":"10.1002","volume":"31","author":[{"given":"Naoaki","family":"Kamiya","sequence":"first","affiliation":[{"name":"Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering, Kyoto University  Katsura, Nishikyo\u2010ku Kyoto 615\u20138510 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