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In this manuscript, a modular, versatile strategy for the synthesis of macrocyclic sulfonamides is described, using consecutive ring expansion reactions. First, linear starting materials are assembled from simple building blocks. This is followed by two distinct cascade ring expansion reaction steps performed in sequence. The utility of this modular approach is showcased via the synthesis of a library of 42 diversely functionalized 13\u2010 and 14\u2010membered macrocyclic sulfonamides. The use of consecutive ring expansions is key to the success of the protocol, ensuring the products are formed in overall good yields without requiring high\u2010dilution conditions.<\/jats:p>","DOI":"10.1002\/chem.202502887","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T07:50:33Z","timestamp":1759305033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modular Assembly of Macrocyclic Sulfonamides via Consecutive Cascade Ring Expansion Reactions"],"prefix":"10.1002","volume":"32","author":[{"given":"Will E.","family":"Orukotan","sequence":"first","affiliation":[{"name":"Department of Chemistry University of York  York YO10 5DD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben. 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