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However, applying photothermal conversion to carry out organic reactions efficiently using carbon nanomaterials remained largely uncharted. To address this, herein, we report for the first time, graphene oxide (GO) as the photothermal agent to perform ring\u2010closing metathesis (RCM) under 940\u00a0nm NIR LED light, as well as solar simulator and natural sunlight, using Grubbs\u2010II catalyst to rapidly synthesize dihydro\u2010pyrroles in high yield with excellent GO recyclability. Theoretical calculation unveiled that this photothermal RCM efficiency originated from the cumulative synergy between substrate\u2010GO absorption energy, activation barrier, and nonradiative relaxation rate which emerged as the predominant contributor for the overall reaction outcome. The RCM product can be further functionalized through Pd\u2010catalyzed Heck coupling to forge various fluorophores for efficient imaging of endoplasmic reticulum (ER), mitochondria, and Golgi apparatus (GA) in HCT\u2010116 colon cancer cells. This GO\u2010mediated photothermal RCM can open a new direction toward synthesizing complex organic molecules with ease and high yield for biomedical applications.<\/jats:p>","DOI":"10.1002\/chem.202502947","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:01:29Z","timestamp":1770710489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Graphene\u2010Oxide\u2010Mediated Photothermal Ring\u2010Closing Metathesis: A Gateway for Organelle Imaging Probes"],"prefix":"10.1002","volume":"32","author":[{"family":"Preeti","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology (IIT) Gandhinagar  Gandhinagar Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5700-0122","authenticated-orcid":false,"given":"Ram","family":"Sewak","sequence":"additional","affiliation":[{"name":"Department 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