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While atomically precise gold nanoclusters (Au\u2010NCs) offer molecule\u2010like control over a metallic core, tuning their optoelectronic behavior via surface engineering is often empirically driven. Here, we establish a design principle by demonstrating that the conformational landscape of intrinsically disordered proteins (IDP) can be used as a programmable scaffold to rationally modulate the photophysical properties of a covalently bound Au\u2010NC. We synthesized a series of bioconjugates between Au\n                    <jats:sub>25<\/jats:sub>\n                    nanoclusters and bioengineered IDPs containing a variable number of cysteine anchoring points. A combination of mass spectrometry, small\u2010angle X\u2010ray scattering, and modeling on the conjugates indicates that increasing the number of covalent anchors systematically restricts the conformational ensemble, inducing a progressively more compact protein shell around nanoclusters. This structural rigidification at the interface directly translates into a 15\u2010fold enhancement of the Au\u2010NC near\u2010infrared photoluminescence and a six\u2010fold increase in its average lifetime. Our findings demonstrate that the conformational plasticity of IDPs and the capacity to engineer them can be harnessed as a molecular tuning knob, moving to a new regime of programmable soft\u2010matter control over the properties of quantum\u2010confined nanomaterials for tailored biotechnological applications.\n                  <\/jats:p>","DOI":"10.1002\/chem.202502991","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T07:26:07Z","timestamp":1769325967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Programming the Optoelectronic Properties of Atomically Precise Gold Nanoclusters Using the Conformational Landscape of Intrinsically Disordered Proteins"],"prefix":"10.1002","volume":"32","author":[{"given":"Santiago","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Centre De Biologie Structurale, Universit\u00e9 de Montpellier INSERM, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Kumanski","sequence":"additional","affiliation":[{"name":"Centre De Biologie Structurale, Universit\u00e9 de Montpellier INSERM, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeineb","family":"Ayed","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Institut pour L'avanc\u00e9e Des Biosciences (IAB), Cancer Targets &amp; Experimental Therapeutics INSERM U1209, CNRS UMR 5309  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Fournet","sequence":"additional","affiliation":[{"name":"Centre De Biologie Structurale, Universit\u00e9 de Montpellier INSERM, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charl\u00e8ne","family":"Bouanchaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon1\u2010CNRS, Institut Lumi\u00e8re Mati\u00e8re, UMR5306 Universit\u00e9 De Lyon  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Sagar","sequence":"additional","affiliation":[{"name":"BicycleTx Ltd., Cambridge CB21 6GS, United Kingdom.  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