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Stable isotope\u2010labeled (SIL) molecules are indispensable tools for investigating chemical and biological mechanisms and quantifying metabolites. However, the late\u2010stage incorporation of isotopically labeled benzene remains challenging and under\u2010investigated. This challenge stems from the direct functionalization of non\u2010substituted benzene, which remains a difficult task. The approach described in this work is based on sulfonium salts used as a source of [\n                    <jats:sup>13<\/jats:sup>\n                    C\n                    <jats:sub>6<\/jats:sub>\n                    ] and [\n                    <jats:sup>2<\/jats:sup>\n                    H\n                    <jats:sub>5<\/jats:sub>\n                    ]benzene under palladium catalysis conditions. This approach demonstrates its efficiency in C\u2500C and C\u2500S bond formation with different substrates. Additionally, this methodology was employed for the synthesis of poly\u2010substituted [\n                    <jats:sup>13<\/jats:sup>\n                    C\n                    <jats:sub>6<\/jats:sub>\n                    ]benzene derivatives.\n                  <\/jats:p>","DOI":"10.1002\/chem.202503170","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:34:51Z","timestamp":1768912491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Late\u2010Stage Phenylation From [\n                    <sup>13<\/sup>\n                    C\n                    <sub>6<\/sub>\n                    ] and [\n                    <sup>2<\/sup>\n                    H\n                    <sub>5<\/sub>\n                    ]Benzene: A Versatile Tool for Stable Isotope Labeled MS 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