{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:11:38Z","timestamp":1790827898935,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P37182"],"award-info":[{"award-number":["P37182"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["AdG C\u2010HANCE 101142915"],"award-info":[{"award-number":["AdG C\u2010HANCE 101142915"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Protecting groups are widely employed in multi\u2010step syntheses with the goal to downregulate the reactivity of certain functional groups. Their use, while often unavoidable, comes with notable drawbacks including increased costs and waste, as well as typically adding two (nonstrategic) synthetic steps to a given sequence. Moreover, late\u2010stage deprotection of highly functionalized compounds can pose challenges. We introduced an approach termed\n                    <jats:italic>deprotective functionalization<\/jats:italic>\n                    , allowing for direct conversion of a protected functional group into a new one without requiring a separate deprotection event. Interestingly, in this paradigm the protecting group not only prevents side reactions, but also primes the protected functionality for selective transformations. This article provides a conceptual framework for this approach and discusses related strategies, currently limited to protected amines.\n                  <\/jats:p>","DOI":"10.1002\/chem.202503271","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:02:16Z","timestamp":1765803736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Deprotective Functionalization: An Emerging Concept for Amine Reactivity"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8949-2958","authenticated-orcid":false,"given":"Irmgard","family":"Tiefenbrunner","sequence":"first","affiliation":[{"name":"Faculty of Chemistry Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2578-6260","authenticated-orcid":false,"given":"Saad","family":"Shaaban","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-0718","authenticated-orcid":false,"given":"Nuno","family":"Maulide","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199620561"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00653"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201901808"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201901621"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-018-0071-1"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC02659J"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.216"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/b821200g"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol020062p"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol036234f"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2009.03.113"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(02)01804-X"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo049405i"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)87069-6"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b03061"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA02242C"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)83645-5"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo991076k"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397910008087243"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo0507643"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)86102-X"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(02)00131-X"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA03683B"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO00352C"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00290a015"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo500492x"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB01290F"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo9919714"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0702728"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.02.034"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00017-3"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00018-5"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318304"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC04974H"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200903050"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202301312"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol701583t"},{"key":"e_1_2_4_39_1","unstructured":"Arguably deprotective functionalization of the tert\u2010butyloxy carbamate may also be possible. However the presence of a conjugated amide is likely to hinder activation making the formation of isocyanate less feasible."},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c06061"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00808a042"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2016.1178776"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b02507"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202503271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202503271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202503271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T13:25:23Z","timestamp":1781961923000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202503271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,1,23]]}},"alternative-id":["10.1002\/chem.202503271"],"URL":"https:\/\/doi.org\/10.1002\/chem.202503271","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"assertion":[{"value":"2025-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03271"}}