{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T13:52:12Z","timestamp":1781963532766,"version":"3.54.5"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Four isomers of [Ru(NO)(QnCN)(Pro)Cl] (\n                    <jats:bold>L1<\/jats:bold>\n                    ,\n                    <jats:bold>D1, L2,<\/jats:bold>\n                    and\n                    <jats:bold>D2<\/jats:bold>\n                    ) were synthesized, where QnCN is 8\u2010hydroxy\u20102\u2010quinolinecarbonitrile and Pro is L\u2010 or D\u2010 proline. Complexes\n                    <jats:bold>L1<\/jats:bold>\n                    and\n                    <jats:bold>D1<\/jats:bold>\n                    ,\n                    <jats:bold>L2<\/jats:bold>\n                    and\n                    <jats:bold>D2<\/jats:bold>\n                    are two pairs of Ru\u2010centered enantiomers. In\n                    <jats:bold>L1<\/jats:bold>\n                    and\n                    <jats:bold>D1<\/jats:bold>\n                    , the proline is coordinated\n                    <jats:italic>trans<\/jats:italic>\n                    to NO, whereas in\n                    <jats:bold>L2<\/jats:bold>\n                    and\n                    <jats:bold>D2<\/jats:bold>\n                    the 8\u2010hydroxy\u20102\u2010quinolinecarbonitrile is coordinated\n                    <jats:italic>trans<\/jats:italic>\n                    to NO. The electronic absorption spectra, infrared (IR), and Raman spectra of the isomers were experimentally measured and theoretically assigned. Ultrasound induces the release of NO from the complexes in solution more rapidly, with a shorter\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    than light does. Moreover, the cytotoxicity of the isomeric complexes against HeLa cells was evaluated; the IC\n                    <jats:sub>50<\/jats:sub>\n                    values range from 1 to 10 \u00b5M, with selectivity indices exceeding 2.8. The complexes induced apoptosis in HeLa cells and arrested the cell cycle at the G2\/M phase. Molecular docking analyses have revealed that the complexes interact with DNA via minor groove binding. The unique stereochemical configurations of the four complexes affect their selective binding to CT\u2010DNA, with DNA binding affinities at 298 K in the following order:\n                    <jats:bold>D1<\/jats:bold>\n                    &gt;\n                    <jats:bold>D2<\/jats:bold>\n                    &gt;\n                    <jats:bold>L1<\/jats:bold>\n                    &gt;\n                    <jats:bold>L2<\/jats:bold>\n                    . This study offers insights into the potential applications of these isomeric nitrosylruthenium complexes.\n                  <\/jats:p>","DOI":"10.1002\/chem.202503317","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T03:50:41Z","timestamp":1765943441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photo and Ultrasound Facilitated the Release of Nitric Oxide From [Ru(NO)(QnCN)(Pro)Cl] Isomers: Synthesis, Cytotoxicity, DNA Binding, and Theoretical Simulation"],"prefix":"10.1002","volume":"32","author":[{"given":"Chenyang","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry Institute of Molecular Science Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry Institute of Molecular Science Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry Institute of Molecular Science Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxiang","family":"Jiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry Institute of Molecular Science Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjie","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry Institute of Molecular Science Shanxi University  Taiyuan 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