{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:32:40Z","timestamp":1787671960366,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chiral salen ligands are a versatile platform for asymmetric catalysis, where understanding their conformational preferences is key to optimizing the stereo\u2010inductive performance of their metal complexes. Here, we examine the conformational landscapes of (\n                    <jats:italic>R<\/jats:italic>\n                    )\/(\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010N,N\u2019\u2010bis(3,5\u2010di\u2010tert\u2010butylsalicylidene)\u20101\u2010methyldiamine ligand and its Cu(II) and Ni(II) complexes in CDCl\n                    <jats:sub>3<\/jats:sub>\n                    solution using vibrational circular dichroism (VCD) and infrared (IR) spectroscopy, supported by extensive conformational searches and DFT calculations. Contrary to its benign reputation, CDCl\n                    <jats:sub>3<\/jats:sub>\n                    profoundly alters the ligand conformational landscape while leaving its metal complexes largely unaffected. This drastic yet selective solvent effect, missed by IR but captured by VCD, is interpreted using a genetic algorithm (GA) approach. Microsolvation modeling with Grimme's quantum cluster growth program reveals how weak solute\u2010solvent van der Waals (vdW) interactions reshape conformational landscapes in CDCl\n                    <jats:sub>3<\/jats:sub>\n                    . The challenges in predicting the outcome of the delicate balance between intra\u2010solute and solute\u2010solvent vdW interactions are discussed in the context of current solvation models.\n                  <\/jats:p>","DOI":"10.1002\/chem.202503460","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:39:38Z","timestamp":1778881178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Solvent\u2010Driven Conformational Landscapes of a Tetradentate Schiff Base Ligand and Its Metal Complexes: A Genetic Algorithm\u2013Guided VCD Investigation"],"prefix":"10.1002","volume":"32","author":[{"given":"Amanda Nhi","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutasem","family":"Alshalalfeh","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colton D.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra Ani\u0163a","family":"Radu","sequence":"additional","affiliation":[{"name":"National College Gheorghe Lazar Sibiu Sibiu 500035 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"\u0162eposu","sequence":"additional","affiliation":[{"name":"National College Gheorghe Lazar Sibiu Sibiu 500035 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cheramy","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zeng","sequence":"additional","affiliation":[{"name":"Foshan Nanhai District Wenhan Middle School Foshan China"},{"name":"Department of Chemistry Xiamen University Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Xiamen University Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin Paul","family":"Nicu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Babe\u0219\u2010Bolyai University  Cluj\u2010Napoca 400028 Romania"},{"name":"C. 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Nenitzescu Institute of Organic and Supramolecular Chemistry Romanian Academy  Bucharest 060023 Romania"},{"name":"Provitam Foundation  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-3190","authenticated-orcid":false,"given":"Yunjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00074"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202104334"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083622"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00912"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.4c01700"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.202000014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011146"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202109345"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202107600"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.9b05638"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202504293"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.23649"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cp42221b"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.1c01503"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28062571"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC02866H"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202307053"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5c02495"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2806192"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201403690"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp801996m"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2023.123634"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2016.00009"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP03408A"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4960653"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CP03869E"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC04329D"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5b00386"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0197592"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CP03028J"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202010055"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310610"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813881"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.2c02953"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.202200161"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<490::AID-JCC1>3.0.CO;2-P"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540110405"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0246313"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30040804"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.464304"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21759"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1884601"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9904009"},{"key":"e_1_2_6_45_1","unstructured":"M. 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