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This transformation is characterized by its mild conditions and excellent functional group tolerance, affording 25 novel tetracyclic compounds in excellent yields (most &gt;85%). The biological evaluation of the obtained tetracyclic products established the scaffold's promising preliminary anti\u2010TNBC profile. The lead compound,\n                    <jats:bold>3ma<\/jats:bold>\n                    , further demonstrated potent anti\u2010migratory effects in wound healing and transwell assay, suggesting anti\u2010metastatic potential. Preliminary mechanistic insights from molecular docking studies indicated binding affinity to the EGFR kinase active site, which provides a testable hypothesis for the mechanism of action.\n                  <\/jats:p>","DOI":"10.1002\/chem.202503547","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T07:14:59Z","timestamp":1769325299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PPh\n                    <sub>2<\/sub>\n                    Me\u2010Promoted [4 + 3] Annulation for Synthesis of Quinazoline\u2010Fused Benzothiadiazepines as Anti\u2010Breast Cancer Agents"],"prefix":"10.1002","volume":"32","author":[{"given":"Peng\u2010Fei","family":"Sun","sequence":"first","affiliation":[{"name":"School of Chemistry and Materials Science Jiangsu Normal University  Xuzhou 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