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Surface\u2010exposed \u03b2\u2010glucans of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    have been identified as promising targets for antifungal vaccine development. However, conventional glycoconjugate vaccines often suffer from limited immunogenicity. Herein, we report an innovative vaccine strategy that recruits endogenous antibodies, such as anti\u2010rhamnose (Rha) antibodies, to improve antigen delivery to antigen\u2010presenting cells (APCs). A redox\u2010responsive disulfide linker was incorporated into the vaccine design to promote endosomal escape and enhance antigen processing. The construct was prepared by conjugating \u03b2\u2010glucans to bovine serum albumin (BSA), followed by coupling Rha haptens via the redox\u2010responsive linker, yielding \u03b2\u2010glucans\u2010BSA\u2010L2\u2010Rha. Immunological evaluations demonstrated that the presence of endogenous anti\u2010Rha antibodies substantially enhanced immune responses, with the redox\u2010responsive glycoconjugate eliciting the strongest reactivity. Moreover, antisera generated by the vaccine effectively recognized the hyphal form of heat\u2010killed\n                    <jats:italic>C. albicans<\/jats:italic>\n                    (HKCA). This study establishes a broadly applicable strategy for the further development of antifungal vaccines.\n                  <\/jats:p>","DOI":"10.1002\/chem.202503568","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:54:19Z","timestamp":1773312859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Redox\u2010Responsive \u03b2\u2010Glucan\u2010Based Vaccine Recruiting Endogenous Antibodies to Potentiate Antifungal Immunity"],"prefix":"10.1002","volume":"32","author":[{"given":"Zhifang","family":"Zhou","sequence":"first","affiliation":[{"name":"The Key Laboratory of Carbohydrate Chemistry &amp; Biotechnology School of Biotechnology Ministry of Education Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Qu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Carbohydrate Chemistry &amp; Biotechnology School of Biotechnology Ministry of Education Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Lin","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Carbohydrate Chemistry &amp; Biotechnology School of Biotechnology Ministry of Education Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Carbohydrate Chemistry &amp; Biotechnology School of Biotechnology Ministry of Education Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peirui","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Carbohydrate Chemistry &amp; Biotechnology School of Biotechnology Ministry of Education Jiangnan University  Wuxi 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