{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:18:06Z","timestamp":1792124286655,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271434"],"award-info":[{"award-number":["32271434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020757","name":"Guangzhou First People's Hospital","doi-asserted-by":"publisher","award":["KY09060001"],"award-info":[{"award-number":["KY09060001"]}],"id":[{"id":"10.13039\/501100020757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020757","name":"Guangzhou First People's Hospital","doi-asserted-by":"publisher","award":["PTHW20231101"],"award-info":[{"award-number":["PTHW20231101"]}],"id":[{"id":"10.13039\/501100020757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020757","name":"Guangzhou First People's Hospital","doi-asserted-by":"publisher","award":["PT32271434"],"award-info":[{"award-number":["PT32271434"]}],"id":[{"id":"10.13039\/501100020757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The detection of unilateral kidney injury remains challenging owing to the intrinsic compensatory mechanism of the kidneys. Noninvasive kidney imaging using renal\u2010clearable near\u2010infrared (NIR) agents has shown promise in evaluating renal function. To enable accurate detection of unilateral kidney injury, herein, we developed a high\u2010contrast NIR imaging agent of 800CW\u2010Au by conjugating IRDye800CW with renal\u2010clearable gold nanoparticles (Au\n                    <jats:sub>25<\/jats:sub>\n                    SG\n                    <jats:sub>18<\/jats:sub>\n                    ). Compared with free IRDye800CW, the pharmacokinetics of the dye was significantly tailored after conjugation on Au\n                    <jats:sub>25<\/jats:sub>\n                    SG\n                    <jats:sub>18<\/jats:sub>\n                    , resulting in enhanced blood retention, reduced vascular extravasation, and lower affinity with background tissue. Consequently, 800CW\u2010Au achieved noninvasive kidney imaging with contrast enhancement &gt; 100% for up to 12\u00a0h, much longer than the previously reported zwitterionic ZW800\u20101 (\u223c10\u00a0min) and PEGylated IRDye800CW (\u223c4\u00a0min). We then established two representative mouse models of unilateral kidney injuries, including unilateral ureteral obstruction and ischemia\u2010reperfusion injury. According to its kinetics of renal enhancement and derived parameters, 800CW\u2010Au sensitively detected the functional impairment in the injured kidney and the compensatory hyperfiltration in the contralateral kidney, which the conventional blood biomarkers and global glomerular filtration rate were all insensitive to detect. This strategy of our work will provide guidance for developing renal NIR agents and advance the noninvasive detection of unilateral kidney injury.\n                  <\/jats:p>","DOI":"10.1002\/chem.202503652","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:04:46Z","timestamp":1773493486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tuning in Vivo Transport of Organic Dyes by Renal\u2010Clearable Gold Nanoparticles for Prolonged Kidney Imaging and Reporting Unilateral Kidney Injuries"],"prefix":"10.1002","volume":"32","author":[{"given":"Yuming","family":"Qi","sequence":"first","affiliation":[{"name":"Center For Medical Research On Innovation and Translation, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Xu","sequence":"additional","affiliation":[{"name":"Center For Medical Research On Innovation and Translation, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunzhi","family":"Wu","sequence":"additional","affiliation":[{"name":"Center For Medical Research On Innovation and Translation, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexi","family":"Peng","sequence":"additional","affiliation":[{"name":"Center For Medical Research On Innovation and Translation, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Center For Medical Research On Innovation and Translation, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixu","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering, Guangzhou International Campus South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoshuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Center For Medical Research On Innovation and Translation, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Center For Medical Research On Innovation and Translation, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingya","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering, Guangzhou International Campus South China University of Technology  Guangzhou P.R. China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P.R. China"},{"name":"Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou PR China"},{"name":"Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of Technology  Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5625-8521","authenticated-orcid":false,"given":"Bujie","family":"Du","sequence":"additional","affiliation":[{"name":"Center For Medical Research On Innovation and Translation, Institute of Clinical Medicine, the Second Affiliated Hospital, School of Medicine South China University of Technology  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf063"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2023.02.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707819"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402479"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201064432\u20109"},{"key":"e_1_2_7_7_1","article-title":"Quantitative Detection of Bilateral and Unilateral Renal Dysfunction by Gold Nanoparticles Through CT Imaging","author":"Yang R.","year":"2025","journal-title":"ACS Nano Medicine"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2021.12.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010021\u201000328\u20106"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215137"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c10143"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202103071"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010018\u20100038\u20103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00819-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507868"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.4c00312"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.9b00707"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202010187"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2468"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102640"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202315457"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807847"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01320"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.170"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201609043"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201511148"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10973"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c11509"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01174"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202511751"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202409477"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1340"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102373"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202503652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.202503652","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.202503652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:41:23Z","timestamp":1781520083000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202503652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,14]]},"references-count":32,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1002\/chem.202503652"],"URL":"https:\/\/doi.org\/10.1002\/chem.202503652","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,14]]},"assertion":[{"value":"2025-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03652"}}