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Herein, we report an activatable dye\u2010sensitized lanthanide nanoprobe (LnNP@ZW800\u2010SC@PEG) with enhanced second near\u2010infrared fluorescence for the real\u2010time imaging of neutrophil\u2010secreted hypochlorite in vivo. By screening of four cyanine derivatives, LnNP@ZW800\u2010SC is identified with the brightest fluorescence at 1523\u00a0nm and the high absolute quantum yield (0.85%) compared to other derivatives. Mechanistic studies reveal that the high conjugation efficiency and enhanced absorption of the ZW800\u2010SC dyes facilitate efficient energy transfer to Yb\n                    <jats:sup>3+<\/jats:sup>\n                    and Er\n                    <jats:sup>3+<\/jats:sup>\n                    , leading to boosted NIR\u2010IIb emission. Leveraging the bright emission, LnNP@ZW800\u2010SC enables high\u2010resolution, sensitive, and specific imaging of hypochlorite, both in vitro and in a murine model of LPS\u2010induced lymphatic inflammation. This work provides a rational design strategy for coordinating dye moieties to enhance dye sensitization, thereby boosting the second near\u2010infrared fluorescence of lanthanides and optimizing their imaging performance for biological applications.\n                  <\/jats:p>","DOI":"10.1002\/chem.70822","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:58:18Z","timestamp":1772960298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Activatable Dye\u2010Sensitized Lanthanide Nanoprobes With Enhanced NIR\u2010II Luminescence for In Vivo Inflammation Imaging"],"prefix":"10.1002","volume":"32","author":[{"given":"Jinzhao","family":"Huang","sequence":"first","affiliation":[{"name":"National Engineering Research Centre for Nanomedicine College of Life Science and Technology Huazhong University of Science and Technology  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8811-5552","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Centre for Nanomedicine College of Life Science and Technology Huazhong University of Science and Technology  Wuhan Hubei P. R. 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