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Their structure, consisting of a \u03b4\u2010lactone and a pyran unit connected by a chiral skipped 1,4\u2010diene, presents a significant synthetic challenge. Herein, we describe a general, modular strategy that enables the synthesis of all naturally occurring jerangolids and their stereoisomers, including the still elusive jerangolid H. The lactone fragment was built through a vinylogous Mukaiyama aldol reaction, with the hydroxymethyl group at C2 introduced in one step by Stille coupling with a novel\n                    <jats:italic>p<\/jats:italic>\n                    \u2010methoxybenzyloxymethyl (PMBM) stannatrane. The stereocenter at both C14 and C15 was generated via deoxygenation of a tertiary alcohol involving a [1,2]\u2010H\u2010shift. Using a highly modular approach recently developed by our group, the jerangolid framework was assembled in a single step through enantioselective \u03c0\u2010allyl Stille coupling of the two key fragments. Synthesis and comparison of both C14 epimers allowed us to unambiguously establish the total configuration of jerangolid H.\n                  <\/jats:p>","DOI":"10.1002\/chem.70928","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:14:53Z","timestamp":1775481293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A General Strategy for the Synthesis of Jerangolids Enabled by \u03c0\u2010allyl Stille Coupling"],"prefix":"10.1002","volume":"32","author":[{"given":"Janick","family":"Schug","sequence":"first","affiliation":[{"name":"Organic Chemistry II Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"B. 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