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Here, we report a concise, scalable three\u2010step synthesis of 4,7\u2010dihydro\u20104,7\u2010ethano\u20102\n                    <jats:italic>H<\/jats:italic>\n                    \u2010isoindole, a key building block of the benzoporphyrin framework. Subsequent functionalization affords the corresponding \u03b1\u2010ester derivative, enabling controlled access to diverse, lower\u2010symmetry benzoporphyrin architectures. Compared with previous multistep strategies, this scalable route markedly reduces cost, waste generation, and synthetic complexity, representing the most practical synthetic approach to date. This advance enhances the synthetic accessibility of benzoporphyrins and paves the way for their broader implementation in molecular materials and biomedical applications.\n                  <\/jats:p>","DOI":"10.1002\/chem.70979","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T06:25:19Z","timestamp":1775629519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sustainable Synthesis of 4,7\u2010Dihydro\u20104,7\u2010ethano\u20102\n                    <i>H<\/i>\n                    \u2010isoindoles\u2014Key Building Blocks to Benzoporphyrins"],"prefix":"10.1002","volume":"32","author":[{"given":"Lampros Pascal","family":"Gazetas","sequence":"first","affiliation":[{"name":"Department of Chemistry and Pharmacy &amp; Interdisciplinary Center for Molecular Materials (ICMM) Organic Chemistry II Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ruppel","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmacy &amp; Interdisciplinary Center for Molecular Materials (ICMM) Organic Chemistry II Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Richtzenhain","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmacy &amp; Interdisciplinary Center for Molecular Materials (ICMM) Organic Chemistry II Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hampel","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmacy &amp; Interdisciplinary Center for Molecular Materials (ICMM) Organic Chemistry II Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-8181","authenticated-orcid":false,"given":"Norbert","family":"Jux","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmacy &amp; Interdisciplinary Center for Molecular Materials (ICMM) Organic Chemistry II Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3093-3624","authenticated-orcid":false,"given":"Dominik","family":"Lungerich","sequence":"additional","affiliation":[{"name":"Univ Toulouse, CNRS CEMES  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)02609\u20105"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14041240"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00177"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TA01846H"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202000860"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301\u20100104(00)00306\u20102"},{"key":"e_1_2_6_8_1","first-page":"2737","article-title":"Nonlinear Optical Properties of Porphyrins","volume":"19","author":"Senge M. 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