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In this work, iridium(III) complexes are prepared with two cyclometalating ligands, either phenylpyridine (ppy) or phenylisoquinoline (piq), and one 6\u2010hydrazinonicotinic acid (HYNIC) ancillary ligand to give [Ir(ppy)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC)]\n                    <jats:sup>+<\/jats:sup>\n                    and [Ir(piq)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC)]\n                    <jats:sup>+<\/jats:sup>\n                    . The extended conjugation in [Ir(piq)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC)]\n                    <jats:sup>+<\/jats:sup>\n                    results in a significant redshift in the absorption and emission properties. Both [Ir(ppy)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC)]\n                    <jats:sup>+<\/jats:sup>\n                    and [Ir(piq)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC)]\n                    <jats:sup>+<\/jats:sup>\n                    generate singlet oxygen upon irradiation with light\u00a0in the presence of oxygen. Irradiation of [Ir(piq)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC)]\n                    <jats:sup>+<\/jats:sup>\n                    (\n                    <jats:italic>\u03bb<\/jats:italic>\n                    <jats:sub>exc<\/jats:sub>\n                    \u00a0= 420\u00a0nm) results in the production of hydroxyl and superoxide radicals. The carboxylic acid functional group in HYNIC has been used to attach a lysine\u2010ureido\u2010glutamatic acid pharmacophore that selectively binds to prostate specific membrane antigen (PSMA) to give HYNIC\u2013PSMA. PSMA is an enzyme that is overexpressed in prostate cancer. HYNIC\u2013PSMA was used to prepare [Ir(ppy)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC\u2013PSMA)]\n                    <jats:sup>+<\/jats:sup>\n                    and [Ir(piq)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC\u2013PSMA)]\n                    <jats:sup>+<\/jats:sup>\n                    . Both complexes bind to cells that overexpress the PSMA enzyme. [Ir(piq)\n                    <jats:sub>2<\/jats:sub>\n                    (HYNIC\u2010PSMA)]\n                    <jats:sup>+<\/jats:sup>\n                    is nontoxic to cells in the dark, but irradiation with visible light results in a dose\u2010dependent cytotoxicity. These complexes have the potential to be of use to identify tumor margins, to guide robot\u2010assisted surgical resection of tumors, as well as for molecularly targeted PDT.\n                  <\/jats:p>","DOI":"10.1002\/chem.71011","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:16:53Z","timestamp":1776493013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phosphorescent Iridium Hydrazinonicotinic Acid (HYNIC) Complexes That Bind to Prostate Specific Membrane Antigen: Potential Photodynamic Therapy of Prostate Cancer"],"prefix":"10.1002","volume":"32","author":[{"given":"La'El","family":"Kimchi","sequence":"first","affiliation":[{"name":"School of Chemistry and Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"McGowan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Morgan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"White","sequence":"additional","affiliation":[{"name":"School of Chemistry and Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor A.","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey E.","family":"Rudd","sequence":"additional","affiliation":[{"name":"School of Chemistry and Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5373-0080","authenticated-orcid":false,"given":"Paul S.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"School of Chemistry and Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrad049"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010021\u201000548\u20103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.245696"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.23335"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00444"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.267783"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550\u2010022\u201000886\u2010y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.263674"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03437"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC05478C"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC07006A"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00211"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2019.10.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00161"},{"key":"e_1_2_7_16_1","first-page":"2022","article-title":"Technetium\u201099m\u2010Human Polyclonal IgG Radiolabeled via the Hydrazino Nicotinamide Derivative for Imaging Focal Sites of Infection in Rats","volume":"31","author":"Abrams M. 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