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This novel methodology provides access to amphipathic \u03b1\u2010CDs equipped with an outward\u2010facing alkyl chain, which self\u2010assemble in water to form linear, head\u2010to\u2010tail supramolecular oligomers (DP up to five CD units) when the alkyl chain is sufficiently short (C8 and C12), and larger nano\u2010objects with a longer C16 chain. Alternatively, permethylated \u03b2\u2010CD analogs bearing an alkyl chain terminated by an adamantyl unit have also been prepared and shown to form similar linear oligomeric material. As a result of the fixed stereochemistry of the quaternary ammonium nitrogen and the blocked narrow opening of the CD, these amphiphilic cationic host molecules are prevented from undergoing self\u2010inclusion or forming head\u2010to\u2010head dimers in water.<\/jats:p>","DOI":"10.1002\/chem.71029","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:30:36Z","timestamp":1776691836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cationic Permethylated Cyclodextrins Capable of Self\u2010Assembling Into Linear Nanostructures in Water"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2888-5087","authenticated-orcid":false,"given":"Maxime","family":"Kolb","sequence":"first","affiliation":[{"name":"\u00c9quipe Confinement Mol\u00e9culaire et Catalyse Institut de Chimie de Strasbourg UMR 7177 CNRS Universit\u00e9 de Strasbourg  Strasbourg Cedex 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