{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:06:14Z","timestamp":1791090374048,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004051","name":"Kato Memorial Bioscience Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,7,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Statine [(3\n                    <jats:italic>S<\/jats:italic>\n                    ,4\n                    <jats:italic>S<\/jats:italic>\n                    )\u20104\u2010amino\u20103\u2010hydroxy\u20106\u2010methylheptanoic acid (Sta)] is a \u03b3\u2010amino acid produced by several microorganisms, including actinomycetes and cyanobacteria. Sta\u2010containing natural products are known to inhibit cathepsin D, a promising therapeutic target for cancer and neurodegenerative diseases. In this study, three new Sta\u2010containing natural products, abastatins A\u2013C, were isolated from a marine\n                    <jats:italic>Okeania<\/jats:italic>\n                    sp. cyanobacterium collected in Japan. Their structures were unambiguously elucidated by spectroscopic analyses combined with derivatization and degradation reactions. To date, Sta\u2010containing natural products have been discovered mainly from marine cyanobacteria; among them, abastatins A\u2013C exhibit the most potent cathepsin D inhibitory activities reported thus far with IC\n                    <jats:sub>50<\/jats:sub>\n                    values in the picomolar range. In addition, we propose plausible docking poses for abastatins A\u2013C bound to cathepsin D and describe a new structure\u2010activity relationship that can enhance inhibitory potency against this enzyme.\n                  <\/jats:p>","DOI":"10.1002\/chem.71051","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:18:08Z","timestamp":1777353488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abastatins A\u2013C: Cathepsin D\u2010Inhibitory Depsipeptides From a Marine\n                    <i>Okeania<\/i>\n                    sp. Cyanobacterium"],"prefix":"10.1002","volume":"32","author":[{"given":"Yuma","family":"Yamaji","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry Chuo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Chuo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arihiro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Chuo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13060837"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201007\u20106276"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.23.259"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9009394"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00551"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MD00017C"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.8b00417"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja001859j"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/np200861n"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7QO00052A"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c00334"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo8012429"},{"key":"e_1_2_8_15_1","unstructured":"MacroModel; Schr\u00f6dinger LLC New York NY 2023."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10635150701472164"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026334"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2109"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10635150390235520"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300\u20109084(96)84768\u20107"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/sys029"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/np030114z"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.04.062"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:02:36Z","timestamp":1783832556000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":22,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2026,7,11]]}},"alternative-id":["10.1002\/chem.71051"],"URL":"https:\/\/doi.org\/10.1002\/chem.71051","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71051"}}