{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:00:29Z","timestamp":1790848829868,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000704","name":"Royal Society of Chemistry","doi-asserted-by":"publisher","award":["C23\u20106688719462"],"award-info":[{"award-number":["C23\u20106688719462"]}],"id":[{"id":"10.13039\/501100000704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/Z515127\/1"],"award-info":[{"award-number":["BB\/Z515127\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The marked influence of organic solvents and water on the conformational preferences of a chiral, soluble 2,6\u2010pyridylcarboxamide foldamer has been established in an array of seventeen distinct solvents\/solvent mixtures. Circular dichroism (CD) spectroscopy has been used to determine the conformational behavior of the soluble PEGylated foldamer as a function of the solvent for aromatic solvents (benzene, toluene and pyridine), chlorinated solvents (chloroform, dichloromethane and tetrachloroethane), polar aprotic solvents (tetrahydrofuran, acetone, acetonitrile, nitromethane, dimethylformamide and dimethylsulfoxide) and polar protic solvents (methanol, methanol\/water mixtures). In aromatic and chlorinated solvents, the foldamer displays pronounced CD signals indicating the adoption of a stable helical conformation in these environments. Notably, even in the presence of polar protic solvents containing high levels of water (of up to 35% water in methanol mixtures), a helical conformation is still adopted by the foldamer, albeit with a less well\u2010defined helical conformation than for other less competitive solvents. These investigations provide crucial insights into the conformational preferences of this foldamer class in a wide range of organic solvents and water mixtures. It is anticipated that this solvent study will prove to be highly important for aiding the future design and operation of functional foldamers, including water compatible systems, in diverse environments.<\/jats:p>","DOI":"10.1002\/chem.71097","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:53:16Z","timestamp":1778241196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Solvent Effects on the Conformational Preferences of 2,6\u2010Pyridylcarboxamide Foldamers"],"prefix":"10.1002","volume":"32","author":[{"given":"Alexander R.","family":"Davis","sequence":"first","affiliation":[{"name":"School of Chemistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushal","family":"Samanta","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Male","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7405-3269","authenticated-orcid":false,"given":"Adam A. L.","family":"Michalchuk","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-0265","authenticated-orcid":false,"given":"Sarah J.","family":"Pike","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2004.1500"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc11137j"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c00625"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b02438"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303135"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201403626"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10758"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC04237H"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07347"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00376"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3OB00473B"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB02512A"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5333.1793"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.3c04907"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004\u2010021\u201000496\u20100"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC03944K"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB02641E"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc31533e"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200701923"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201602481"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201405792"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja044392b"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072642799"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja002129e"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527611478.ch3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol036238k"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC00430C"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199404461"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0547228"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja066126z"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","unstructured":"S. J.Pike R.Telford andL.Male \u201cReversible Conformational Switching of a Photo\u2010Responsive Ortho\u2010Azobenzene\/2 6\u2010Pyridyldicarboxamide Heterofoldamer \u201d21(2023):7717\u20137723 http:\/\/doi.org\/10.1039\/D3OB01137B.","DOI":"10.1039\/D3OB01137B"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00048"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CE00728E"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5OB00342C"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202402423"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202402892"},{"key":"e_1_2_7_38_1","unstructured":"The helical pitch for4is measured from the C atoms of the terminal amide functionalities in line with other foldamers within this class."},{"key":"e_1_2_7_39_1","unstructured":"In the CD spectra of1 the minima at 466\u2010475\u00a0nm similarly display variations in the magnitude of the Cotton effects in the different tested solvents; see Supporting Information."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.27344"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja983995i"},{"key":"e_1_2_7_42_1","volume-title":"Practical Organic Chemistry","author":"Vogel A. 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