{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:32:30Z","timestamp":1787671950918,"version":"build-2736575974"},"reference-count":78,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A catalyst\u2010free direct C\u2010H cyanation of arenes was performed in continuous flow by treating aromatic substrates in acetonitrile with an argon plasma in a gas\u2013liquid microreactor under ambient conditions. The reactivity of the different radicals generated through plasma activation of acetonitrile was probed using benzene as a model substrate, producing benzonitrile in a 25% yield. Mechanistic insights derived from kinetic modeling and isotopic labeling experiments enabled the proposal of a reaction pathway accounting for the formation of the main nitrile products. Expanding the substrate scope demonstrated consistent nitrile formation aligned with the mechanistic hypothesis. This catalyst\u2010free direct C\u2010H cyanation of arenes using an accessible and low\u2010toxicity nitrile source highlights the promising role of plasma activation as an alternative tool for organic\u00a0transformations.<\/jats:p>","DOI":"10.1002\/chem.71101","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:52:58Z","timestamp":1778680378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Catalyst\u2010Free Cyanation of Arenes by Acetonitrile in a Plasma\u2013Liquid Microreactor"],"prefix":"10.1002","volume":"32","author":[{"given":"Pierre","family":"Dedieu","sequence":"first","affiliation":[{"name":"Institut de Recherche de Chimie Paris, UMR 8247 Chimie ParisTech \u2010 PSL Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Morand","sequence":"additional","affiliation":[{"name":"Institut de Recherche de Chimie Paris, UMR 8247 Chimie ParisTech \u2010 PSL Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Ognier","sequence":"additional","affiliation":[{"name":"Institut de Recherche de Chimie Paris, UMR 8247 Chimie ParisTech \u2010 PSL Paris France"},{"name":"UFR Chimie Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Favre\u2010R\u00e9guillon","sequence":"additional","affiliation":[{"name":"Institut de Recherche de Chimie Paris, UMR 8247 Chimie ParisTech \u2010 PSL Paris France"},{"name":"EPN 7 \u201dChimie, Sant\u00e9 Vivant\u201d Conservatoire National des Arts et M\u00e9tiers La Plaine Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tatoulian","sequence":"additional","affiliation":[{"name":"Institut de Recherche de Chimie Paris, UMR 8247 Chimie ParisTech \u2010 PSL Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100762r"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15583724.2013.776586"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0103266"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c02283"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b03916"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c00422"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.01.033"},{"issue":"30","key":"e_1_2_6_10_1","first-page":"5590","article-title":"Copper\u2010Catalyzed Oxidative Cyanation of Aryl Halides With Nitriles Involving Carbon\u2013Carbon Cleavage","volume":"24","author":"Song R.\u2010J.","year":"2012","journal-title":"Organic Letters"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02265"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c05836"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201305731"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC04437F"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201501823"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201005121"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2018.09.027"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c00814"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b00886"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c01963"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol401404y"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201409247"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b04639"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201303637"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201805772"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201309791"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202316108"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c10303"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6356"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b02678"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jechem.2022.02.054"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b12708"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011815"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c00203"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c00929"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202103777"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17939-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b04586"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201206168"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c01029"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707517"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogsc.2016.12.001"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.1c04031"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11090-010-9234-7"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11090-019-09993-6"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.201600079"},{"key":"e_1_2_6_47_1","doi-asserted-by":"crossref","unstructured":"P.Cools L.Astoreca P. S.Esbah Tabaei M.Thukkaram H.De Smet R.Morent andN.De Geyter \u201cSurface Treatment of Polymers by Plasma \u201d inSurface Modification of Polymers: Methods and Applications(Wiley\u2010VCH 2019) 31\u201365.","DOI":"10.1002\/9783527819249.ch2"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2018.03.009"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.200600087"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11090-020-10135-6"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC01157A"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.202400149"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogsc.2025.101029"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1088\/0963-0252\/25\/5\/053002"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RE00122G"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC01940J"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC00942D"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202301666"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RE00464F"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11090-020-10140-9"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5GC02405F"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.201700188"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11090-016-9742-1"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6595\/abe11c"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.5059\/yukigoseikyokaishi.34.36"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo01324a019"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar00090a002"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-6090(02)00034-2"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4LC00315B"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511546075"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSA.63.001185"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93768-7"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal13040761"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00347a049"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1039\/p19850002123"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201204483"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2509(97)00114-0"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2509(97)00217-0"},{"key":"e_1_2_6_79_1","doi-asserted-by":"crossref","unstructured":"V.vanSteijn M. T.Kreutzer andC. R.Kleijn \u201c\u00b5\u2010PIV Study of the Formation of Segmented Flow in Microfluidic T\u2010Junctions\u201dhttps:\/\/doi.org\/10.1016\/j.ces.2007.08.068.","DOI":"10.1016\/j.ces.2007.08.068"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:11:32Z","timestamp":1787670692000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":78,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2026,8,24]]}},"alternative-id":["10.1002\/chem.71101"],"URL":"https:\/\/doi.org\/10.1002\/chem.71101","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71101"}}