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This approach integrates sulfur atoms that enhance intersystem crossing (ISC) to the triplet state via spin\u2010orbit coupling, positioning these photosensitizers as suitable candidates for photodynamic therapy applications. In this study, we investigate the photophysical properties and excited\u2010state dynamics of 4\u2010dimethylaminophthalimide (DMAP) and its thionated derivative, thio\u20104\u2010dimethylaminophthalimide (SDMAP). DMAP exhibits a fluorescence quantum yield of 17%, demonstrating significant fluorescence emissions. In contrast, SDMAP shows negligible fluorescence due to enhanced ISC within 1.0\u00a0\u00b1\u00a00.2\u00a0ps, which facilitates the rapid triplet state population, with a lifetime of 3.40\u00a0\u00b1\u00a00.05\u00a0\u00b5s under argon\u2010saturated conditions. Notably, the triplet state of SDMAP generates singlet oxygen with a quantum yield of 0.83\u00a0\u00b1\u00a00.05, highlighting its high potential for photodynamic therapy. In comparison, DMAP does not produce singlet oxygen and undergoes radiative and nonradiative decay to the ground state within 5\u00a0\u00b1\u00a01\u00a0ns. These findings underscore the profound impact of thionation, effectively converting DMAP from a relatively fluorescent molecule into a highly efficient photosensitizer for photocatalysis and deep\u2010tissue photodynamic therapy applications.<\/jats:p>","DOI":"10.1002\/chem.71137","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:24:28Z","timestamp":1779096268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Double Thionation of 4\u2010Dimethylaminophthalimide Leads to the Development of a Highly Effective Photosensitizer"],"prefix":"10.1002","volume":"32","author":[{"given":"Chris","family":"Acquah","sequence":"first","affiliation":[{"name":"Department of Chemistry Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry 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