{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:09:28Z","timestamp":1789193368586,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K1792403"],"award-info":[{"award-number":["23K1792403"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26H00392"],"award-info":[{"award-number":["26H00392"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,9,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, we introduce\n                    <jats:italic>persistent molecular confinement<\/jats:italic>\n                    , a kinetically enforced encapsulation state in which guest release is suppressed by asymmetric gating. Using a Keplerate\u2010type polyoxometalate, {Mo\n                    <jats:sub>132<\/jats:sub>\n                    }, we demonstrate that it functions as an inorganic carcerand cage capable of confining bulky organic molecules. Despite narrow pore apertures, bulky polar organic guests can enter the inner cavity under thermal or mechanochemical activation. Systematic guest screening implies that dipole\u2010driven attractive interactions facilitate ingress of bulky polar guests, whereas nonpolar analogues are excluded. Once encapsulated, rigid bulky guests are not released even upon exposure to organic media and remain confined under ambient conditions for weeks. This effectively irreversible retention suggests an intrinsic asymmetry between the uptake and release pathways rather than exceptionally strong binding.\u00a0Interaction between the macrocyclic pore and an incoming guest may induce transient \u201cinduced\u2010fit\u201d\u2010like pore adaptation, whereas the reverse process likely involves a substantially higher kinetic barrier, possibly due to steric constraints at the interior side. Kinetic analysis indicates that the irreversible uptake of rigid bulky guests arises from a large, entropically dominated large activation barrier for release, consistent with asymmetric gating behavior. These findings highlight asymmetric gating as a principle for achieving kinetically persistent molecular confinement.\n                  <\/jats:p>","DOI":"10.1002\/chem.71227","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T03:55:07Z","timestamp":1780804507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inorganic Carcerand: Kinetically Persistent Confinement Through Asymmetric Gating"],"prefix":"10.1002","volume":"32","author":[{"given":"Akari","family":"Nakashuku","sequence":"first","affiliation":[{"name":"Graduate School of Environmental Science Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinatsu","family":"Murata","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental Science Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeseob","family":"Shin","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental Science Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoka","family":"Sato","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental Science Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuaki","family":"Konishi","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental Science Hokkaido University  Sapporo Japan"},{"name":"Faculty of Environmental Earth Science and Graduate School of Environmental Science Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar9001203"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200805340"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr4001226"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar068185n"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/356029a0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00294a076"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00007a060"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00097H"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19981231)37:24<3359::AID-ANIE3359>3.0.CO;2-J"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4DT02114B"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs35169b"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/a901436e"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja900452d"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201603596"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201101454"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC06875C"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218897"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201005596"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt30502j"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja304513t"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b01526"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b01516"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03542"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC06217C"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202100899"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202302328"},{"key":"e_1_2_7_28_1","unstructured":"Winmostar V10 X\u2010Ability Co. 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