{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:39:47Z","timestamp":1791463187050,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001775","name":"University of Technology Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines. In this work a new family of squaramide anion transporters appended with two different lysosome targeting groups via a 1,4\u2010substituted benzene spacer were synthesised. Cell viability studies showed that the transporters containing the\n                    <jats:italic>N,N<\/jats:italic>\n                    \u2010dimethylamine targeting group exhibited the greatest cytotoxic effects despite possessing lower transport activities than the non\u2010targeted control compounds and those containing the morpholine targeting group. Subcellular localisation studies using anthracene\u2010labelled squaramides found that both targeting motifs successfully directed compounds to the lysosome, but the morpholine\u2010containing motif accumulated to a lesser extent.\n                  <\/jats:p>","DOI":"10.1002\/chem.71243","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:12:01Z","timestamp":1781003521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lysosome\u2010Targeted Squaramide Anion Transporters"],"prefix":"10.1002","volume":"32","author":[{"given":"Elba","family":"Feo","sequence":"first","affiliation":[{"name":"School of Mathematical and Physical Sciences Faculty of Science University of Technology Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"York","sequence":"additional","affiliation":[{"name":"School of Mathematical and Physical Sciences Faculty of Science University of Technology Sydney Sydney New South Wales Australia"},{"name":"Faculty of Science and Engineering Zernike Institute For Advanced Materials University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Thai","sequence":"additional","affiliation":[{"name":"School of Mathematical and Physical Sciences Faculty of Science University of Technology Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Ryder","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"McNaughton","sequence":"additional","affiliation":[{"name":"Monash Institute of Pharmaceutical Science Monash University Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-4910","authenticated-orcid":false,"given":"Philip A.","family":"Gale","sequence":"additional","affiliation":[{"name":"School of Mathematical and Physical Sciences Faculty of Science University of Technology Sydney Sydney New South Wales Australia"},{"name":"Faculty of Science and Engineering Zernike Institute For Advanced Materials University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC04242C"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01315-w"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041488"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2019.05.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2706"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2024.102535"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2024.07.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201200729"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA02146C"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB01957F"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127461"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo035546t"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00269a003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo100104g"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201800188"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC03888C"},{"key":"e_1_2_7_18_1","unstructured":"Bindfit accessed 09\/12\/2025 http:\/\/supramolecular.org."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10610278.2021.1999956"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b02163"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081202"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00075"},{"key":"e_1_2_7_23_1","unstructured":"MolGpKa accessed 09\/12\/2025 https:\/\/xundrug.cn\/molgpka."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1981.61.2.296"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp200641e"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.050054"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1545"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114313"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1872-2040(21)60108-1"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901457w"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b02459"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b00806"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2020.129363"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1474-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049366"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.1c01363"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(02)00226-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:11:34Z","timestamp":1790251894000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":37,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2026,9,24]]}},"alternative-id":["10.1002\/chem.71243"],"URL":"https:\/\/doi.org\/10.1002\/chem.71243","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"2025-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71243"}}