{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:02:16Z","timestamp":1790254936518,"version":"4.1.0"},"reference-count":106,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22571307"],"award-info":[{"award-number":["22571307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The manganese\u2010catalyzed asymmetric transfer hydrogenation of ketones with chiral N\n                    <jats:sub>6<\/jats:sub>\n                    \u2010macrocyclic ligands is reported. Employing 2\u2010propanol as the hydrogen source, a broad range of chiral alcohols were obtained with excellent yields and enantioselectivities (up to 99% yield and 99% ee) under mild conditions with a catalyst loading of 1\u00a0mol %. Density functional theory calculations reveal that an isopropanol molecule participates in the transition states, and multiple noncovalent interactions among the macrocyclic ligand, the isopropanol molecule, and the ketone substrate exist, accounting for the unique macrocyclic effect and revealing the origin of product chirality. Moreover, an investigation of iridium\u2010catalyzed asymmetric transfer hydrogenation using these chiral N\n                    <jats:sub>6<\/jats:sub>\n                    \u2010macrocyclic ligands (2\u00a0mol %) demonstrates the superior performance of the manganese catalysts in comparison with their iridium counterparts.\n                  <\/jats:p>","DOI":"10.1002\/chem.71244","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:14:58Z","timestamp":1781583298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Manganese\u2010Catalyzed Asymmetric Transfer Hydrogenation of Aromatic Ketones With Chiral N\n                    <sub>6<\/sub>\n                    \u2010Macrocyclic Ligands"],"prefix":"10.1002","volume":"32","author":[{"given":"Faju","family":"Li","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences (CAS)  Beijing P. R. China"},{"name":"Key Laboratory of Forensic Toxicology Ministry of Public Security, Forensic Science Service of Beijing Public Security Bureau  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Peng","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences (CAS)  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhong","family":"Long","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences (CAS)  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai\u2010Hu","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences (CAS)  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Mei","family":"He","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences (CAS)  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0483-8786","authenticated-orcid":false,"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences (CAS)  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-2239","authenticated-orcid":false,"given":"Qing\u2010Hua","family":"Fan","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences (CAS)  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010105)40:1<40::AID-ANIE40>3.0.CO;2-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/B513396C"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar700134q"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.200800196"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11244-010-9559-8"},{"key":"e_1_2_7_7_1","first-page":"291","article-title":"Metal\u2010catalyzed Asymmetric Hydrogenation of Ketones","volume":"68","author":"Chen G.\u2010Q.","year":"2021","journal-title":"Advances in Catalysis"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.8b00774"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00764"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202425589"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201102710"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05738"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-020-0474-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c13273"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09266"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202303007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c11149"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202415171"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.024.202303801"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c15673"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61360-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c04856"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202512543"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/b806837m"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CY00390A"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00043"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201800053"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00212"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00082E"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202208003"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202303412"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202400352"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202301567"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201709010"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogsc.2021.100511"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00093H"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214421"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03709"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702406"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201700042"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar9502341"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.200390030"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/b618340a"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00203"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.201600084"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214893"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705471"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CY01601E"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212479"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CY00446H"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201814751"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006383"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201900671"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b01056"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c04206"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcat.2023.01.006"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO00518F"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c04979"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.6023\/A25030092"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5SC02606G"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.8b00625"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2020.106040"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.10.023"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1DT02257A"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202201522"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcat.2024.115682"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcat.2024.114274"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA03062E"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201601057"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2017.10.028"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1611669"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.9b00457"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c00616"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcat.2024.115758"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5c01944"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202311896"},{"key":"e_1_2_7_77_1","first-page":"476","article-title":"Asymmetric Supramolecular Catalysis Based on Macrocyclic Host Molecules","volume":"30","author":"Tang Y.","year":"2018","journal-title":"Progress in Chemistry"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202502040"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00583"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202202972"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00161"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar500146e"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/128_2013_480"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201812647"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909919"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205739"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.024.202404070"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c14310"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202402081"},{"key":"e_1_2_7_90_1","first-page":"43113","article-title":"Unusual Regioselectivity in Pd\u2010Catalyzed Heterogeneous Aromatic Hydrogenation of PV\u2013Functionalized Naphthalene Derivatives","volume":"147","author":"Meng Q.","year":"2025","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202500945"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00013a015"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-1650(78)80079-8"},{"key":"e_1_2_7_94_1","volume-title":"Gaussian 16","author":"Frisch M. J.","year":"2016"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.33.8822"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1039\/b508541a"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.463096"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.467146"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.38.3098"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.37.785"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.464913"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100096a001"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp810292n"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct100466k"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202000186"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202009754"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71244","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:11:36Z","timestamp":1790251896000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":106,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2026,9,24]]}},"alternative-id":["10.1002\/chem.71244"],"URL":"https:\/\/doi.org\/10.1002\/chem.71244","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"2026-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71244"}}