{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:00:24Z","timestamp":1790848824008,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22225401"],"award-info":[{"award-number":["22225401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M731049"],"award-info":[{"award-number":["2023M731049"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The detection sensitivity of surface\u2010enhanced Raman scattering (SERS) depends on high\u2010density electromagnetic \u201chotspots\u201d within metallic nanostructures. However, conventional salt\u2010induced aggregation often leads to uncontrolled clustering, resulting in uneven hotspot distribution and occasional macroscopic precipitation. Here, we report a Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010assisted spatially confined etching strategy for precise fabrication of silver\u2010based core\u2013satellite nanostructures (SGSI), using silver\u2010graphene nanoparticles (Ag@G) as a template. Finite\u2010difference time\u2010domain (FDTD) simulations confirm that nanogaps within the satellite architecture induce strong plasmonic coupling, generating highly localized electromagnetic fields. Benefiting from uniformly distributed intra\u2010cavity hotspots and excellent colloidal stability, the substrate exhibits high SERS activity and signal reproducibility. The superior performance arises from two synergistic effects: (i) carboxyl inherent to the graphene shell of Ag@G imparts a negative surface potential, promoting the electrostatic adsorption of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    ions and accelerating the etching process; and (ii) the graphene shell also serves as a permeable physical barrier that provides a spatial confinement effect, guiding Ag reorganization into stable satellite structures. This satellite platform enables highly sensitive detection of the anticancer drug methotrexate (55\u00a0nM) in mice serum. Overall, this work offers a new paradigm for constructing a high\u2010performance and stable SERS sensing platform via the synergistic regulation of surface charge and spatial confinement effects.\n                  <\/jats:p>","DOI":"10.1002\/chem.71308","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:02:27Z","timestamp":1782259347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fe(III)\u2010Induced Satellite Structural Evolution of Ag@G Nanoparticles Toward Ultrasensitive Detection of Trace Drugs in Mice Serum"],"prefix":"10.1002","volume":"32","author":[{"given":"Yemawaysh Zewdie","family":"Sholo","sequence":"first","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering College of Environmental Science &amp;Engineering Hunan University  Changsha 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Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering College of Environmental Science &amp;Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwen","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering College of Environmental Science &amp;Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girum Girma","family":"Bizuneh","sequence":"additional","affiliation":[{"name":"Hunan Hongyue New Energy Materials Recycling Co.Ltd  Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumian","family":"Cao","sequence":"additional","affiliation":[{"name":"Shenyang Institute of Automation Chinese Academy of Sciences  Shenyang Liaoning 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